摘要
目的本文用放射免疫分析法(RIA)检测糖尿病肾病患者血清中肝纤维化标志物透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)和Ⅳ型胶原(Ⅳ-C),探讨其对糖尿病肾病的临床诊断、疗效观察、预后判断等应用价值。方法对糖尿病肾病患者37例,健康体检者25例血清HA、LN、PCⅢ及Ⅳ-C进行检测。结果糖尿病肾病血清中HA、LN、PCⅢ及Ⅳ-C含量与对照组相比均有不同程度的升高(P<0.01或0.05)。结论血清中HA、LN、PCⅢ及Ⅳ-C检测可较好地反映糖尿病肾病患者肾纤维化程度,在肾纤维化的诊治及预后方面有较高价值。
Objective To measure serum HA, LN, PCⅢ, and Ⅳ-C levels with radioimmunoassay （RIA） in patients with diabetic nephropathy （DN）, and to evaluate the measurement value in DN diagnosis, therapeutical effect, and prognosis. Methods The serum level of HA, LN, PCⅢ and Ⅳ-C in 37 patients with various types of diabetic nephropathy and 25 controls were measured with RIA. Results The serum level of HA, LN, PCⅢ and Ⅳ-C in patients of various types were significantly higher than those in controls （P〈0.01 or 〈0.05） with the progress of liver diseases process toward development of cirrhosis. Conclusion Measurement of serum level of H A,LN, PC Ⅲ and Ⅳ-C is of important value for reflection of the degree of hepatic fibrosis, and valuable for diagnosis, treatment and prognosis of diabetic nephropathy.
出处
《检验医学与临床》
CAS
2007年第3期168-169,共2页
Laboratory Medicine and Clinic
