摘要
目的：比较阴道给米索前列醇与静脉滴注缩宫素对足月引产的有效性及安全性。方法：５０例产妇（初产妇４９例、经产妇１例）年龄２０～４０ａ，妊娠３７．６～４２．４ｗｋ，随机分为２组，各２５例。Ａ组用米索前列醇１片（５０μｇ／片）阴道给药，４～６ｈ重复直至临产。Ｂ组用静脉滴注缩宫素２．５～５ＩＵ。结果：用药后６ｈＡ组比Ｂ组宫颈Ｂｉｓｈｏｐ评分改善更明显（Ｐ＜０．０５）；从给药引产到阴道分娩的时间短，但无统计学差异（１１±５ｈｖｓ１５±７ｈ，Ｐ＞０．０５）；引产成功率高（８８％ｖｓ４４％，Ｐ＜０．０１）；２组均未发现明显副作用。结论：阴道给米索前列醇较静脉滴注缩宫素足月引产的成功率高。
AIM:To compare the efficacy and safety of misoprostol and oxytocin for induced term labor.METHODS:Fifty women of 20-40 a at 37.6-42.4 wk of pregnancy with indications for induced labor and with no contraindication of prostaglandins were randomly allocated into two groups. Group A:misoprostol 50 μg/tablet was inserted into the posterior fornix of vagina every 4-6 h up to in labor.Group B:oxytocin 2.5-5IU in 5% glucose 500 mL iv gtt was given continuously up to labor onset.The cervical Bishop score was evaluated before and every 6 h induced labor.RESULTS:The cervical Bishop score was improved more significantly in the group A than in group B( P<0.05) .The intervals from induction to expulsion in group A and group B were 11.3 h and 15.3h,respectively(P >0.05) .The rate of success was higher in the group A (88%)than that of the group B(44%)(P<0.01).No obvious side effects were found in both groups. CONCLUSION:Intravaginal administration of misoprostol is a safe and effective method for induced labor in the late trimester of pregnancy.
出处
《新药与临床》
CSCD
北大核心
1996年第4期220-222,共3页
关键词
米索前列醇
缩宫素
人工引产
药物引产
misoprostol
oxytocin
induced labor
third pregnancy trimester
