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IL-6与子宫内膜异位症发病关系的研究 被引量：5

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摘要 子宫内膜异位症（endometriosis，内异症）虽是良性疾病但却有恶性行为。近年细胞因子与内异症的关系倍受重视。IL-6是分子量为19—28kD的糖蛋白，具有复杂生物学功能的多源性细胞因子，在宿主（患者）抵御组织损伤过程中起重要作用，与临床许多疾病的发生和转归密切相关。IL-6分泌或表达异常可导致一系列疾病发生。本研究采用ELISA方法检测30例内异症患者血液及腹腔液中IL-6的水平并用免疫组化法检测了IL-6在患者异位组织的表达，探讨了IL-6与内异症发病的关系及其临床意义。
作者 徐洪云 曹玉民 李建霞 任淑文
机构地区 青岛市第八人民医院妇产科
出处 《现代妇产科进展》 CSCD 北大核心 2007年第1期57-59,共3页 Progress in Obstetrics and Gynecology
关键词 子宫内膜异位症 白细胞介素6 异位内膜
分类号 R714.3 [医药卫生—妇产科学]
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参考文献9

  • 1Harada T,Yoshioka H,Yoshida S,et al.Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis[J].Am J Obstet Gynecol,1997,176:593-597
  • 2Berek JS,Chung C,Kaldi K,et al.Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer[J].Am J Obstet Gynecol,1991,164:1038-1042
  • 3Punnonen J,Teisala K,Ranta H,et al.Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis[J].Am J Obstet,1996,174:15-22
  • 4Witz CA.Interleukin-6:another piece of the endometriosis-cytokine puzzle[J].Fertil Steril,2000,73:212-214
  • 5Kyama CM,Overbergh L,Debrock S,et al.Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis[J].Fertil Steril,2006,85(6):1667-1675
  • 6Lebovic DI,Bentzien F,Chao VA,et al.Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin 1 beta[J].Mol Hum Reprod,2000,6:269-275
  • 7Tsudo T,Harada T,Iwabe T,et al.Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues[J].Fertil Steril,2000,73:205-211
  • 8张君娜,陈素琴,周娜静,冯卿卿,王江莉,杨素娟,范秀华.AHSG和IL-6基因多态性与Ⅳ期卵巢子宫内膜异位囊肿的相关性研究[J].现代妇产科进展,2006,15(5):346-349. 被引量：3
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二级参考文献9

  • 1Dogan S,Machicao F,Wallwiener D,et al.Association of peroxisome proliferator-activated receptor gamma 2 Pro12-Ala polymorphism with endometriosis[J].Fertil Steril,2004,81:1411-1413
  • 2Mathur SP,Holt VL,Lee JH,et al.Levels of transferrin and alpha2-hs glycopro-tein in women with and without endometriosis[J].Autoimmunity,1999,29:121-127
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  • 5Cox DW,Andrews B J,Wills DE,et al.Genetic polymorphism of alpha 2bs-glycoprotein[J].Am J Hum Genet,1986,38:699-706
  • 6Kim H,Ku SY,Kim SH,et al.Association between human alpha 2-Heremans Schmidt glycoprotein(AHSG) polymorphism and endometriosis in Korean women[J].Fertil Steril,2004,82:1497-500
  • 7Fritz Wieser MD,Gerhild Fabjani,Clemens Tempfer MD,et al.Analysis of an interleukin-6 gene promoter polymorphism in women with endometriosis by pyrosepuencing[J].J Soc Gynecol Investig,2003,10:32-36
  • 8Bhanoori M,Babu KA,Deenadayal M,et al.The interleukin-6-174G/C promoter polymorphism is not associated with endometriosis in South Indian women[J].J Soc Gynecol Investig,2005,12:365-369
  • 9马莎,蒋凌月,武绍远,徐艳,严新民,张金章.IL-6基因调控区-174G/C多态性与急性脑梗死的关系[J].中风与神经疾病杂志,2003,20(2):152-154. 被引量：3

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现代妇产科进展
2007年 第1期

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