摘要
目的:对小细胞肺癌的化疗、放疗、预防性全脑放疗及靶向治疗等方面的进展进行探讨。方法:收集国外相关文献进行归纳分析。结果及结论:小细胞肺癌恶性度高,常常快速播散和转移,联合化疗是主要的治疗方法,依托泊苷联合铂类的2药联合化疗4个～6个周期是标准的一线治疗;身体状况好的局限期患者推荐同步化放疗(EP方案),超分割放疗优于每日1次放疗,序贯治疗时患者也宜早期接受放疗,放疗可在化疗的第1或第2周期开始(1.5Gy,每日2次,总量45Gy;或是1.8Gy,每日1次,总量50Gy);预防性全脑放疗可使完全缓解的局限期患者生存延长;靶向治疗仍需要进一步探索。
OBJECTIVE i To discuss the progress in the chemotherapy, radiotherapy, preventive radiotherapy of whole brain, targeted therapy etc. for small cell lung cancer （SCLC）. METHODS： Meta - analysis was conducted on the related literatures both home and abroad. RESULTS ＆ CONCLUSION： SCLC is highly malignant, fast spread and metastasized. The major therapeutic principle for SCLC is a combination chemotherapy regimen with etoposide plus cisplatin or carboplatin for 4 6 weeks. Concurrent chemotherapy （EP regimen） was recommended for those patients in localized stage with good physical status. Hyperfractionation is superior to chemotherapy （q. d）. For those patients receiving sequential therapy, radiotherapy is suggested to be started in the early stage, either on the first week or the second week （1.5 Gy/ b. i. d, total 45 Gy ; or 1.8 Gy/q. d, total 50Gy）. Preventive radiotherapy of whole brain can prolong the survival time of patients in localized stage with complete remission. Further study remains to be done in targeted therapy.
出处
《中国医院用药评价与分析》
2007年第1期11-16,共6页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
小细胞肺癌
化疗
放疗
预防性全脑放疗
靶向治疗
small cell lung cancer
chemotherapy
radiotherapy
prophylactic radiotherapy of whole brain
targeted therapy
