摘要
目的观察杏芎氯化钠注射液(美托康注射液)治疗不稳定型心绞痛(UAP)的临床疗效,及其对血浆低密度脂蛋白-胆固醇(LDL-C)、D-二聚体(DD)、纤维蛋白原(Fg)、C-反应蛋白(CRP)水平的影响。方法98例UAP患者随机分为对照组(n=46)和美托康组(n=52)。对照组采用常规治疗(硝酸酯类药物、阿司匹林、β-受体阻滞剂及他汀类药物等);美托康组在常规治疗的基础上,静脉滴注美托康注射液250mL/d10～14d。分别观察两组治疗前后胸痛发作次数、心电图的变化及LDL-C、DD、Fg、CRP的水平。结果美托康组临床治疗总有效率显著高于对照组(P<0.05);对照组与美托康组Fg治疗后与治疗前的差值之间比较差异无统计学意义(P>0.05);美托康组LDL-C、DD和CRP治疗后的降低程度较对照组更为显著(P<0.05)。结论杏芎氯化钠注射液治疗UAP有良好的临床疗效,并可有效降低UAP患者血浆LDL-C、DD和CRP的水平。
Objective To observe the curative effect of the sodium chloride injection containing Ginkgo biloba extract and ligustrazine phosphate （ Maitork injection） for unstable angina pecturisl UAP）and study the effect of Maitork on plasma levels of low - density lipoprotein - cholesterol （ LDL - C ）, D - Dimer （ DD）, fibrinogen （Fg）, C - reactive protein （ CRP） in the patients with UAP. Methods 98 patients with UAP were randomly divided into Maitork group （n =52） and control group （n =46）. Conventional therapy （nitrate, β -blocker, aspirin, statin etc. ）was used in the control group; 250 ml/d Maitork injection iv gtt were given to the Maitork group for 10 - 14 days, besides the conventional therapy. The clinical symptoms, ECG and plasma levels of LDL -C, DD, Fg, CRP of the two groups were observed, Result The total effective rates were significantly higher in Maitork group than in control group （ P 〈 0. 05 ）. Plasma levels of LDL -C, DD and CRP were reduced after the treatment in two groups, but the decrease was mere significant in Maitork than in control group （ P 〈0. 05 ）, the decrease of Fg was not obviously different between the two groups （ P 〉 0. 05 ）. Conclusion The obvious curative effect of the sodium chloride injection containing Ginkgo biloba extract and ligustrazine phosphate was verified for UAP. Maitork injection can effectively reduce the plasma levels of LDL - C, DD and CRP in the patients with UAP.
出处
《中国急救医学》
CAS
CSCD
北大核心
2007年第3期218-220,共3页
Chinese Journal of Critical Care Medicine
关键词
美托康
不稳定型心绞痛
低密度脂蛋白-胆固醇
D-二聚体
纤维蛋白原
C-反应蛋白
Maitork injection
Unstable angina pectoris（UAP）
Low- density lopoprotein cholesterol（LDL-C）
D -Dimer（DD）
Fibrinogen
C -reactive protein（CRP）
