摘要
目的:制备复方奥硝唑甲磺酸培氟沙星缓释牙栓,并建立质量控制标准。方法:以奥硝唑甲磺酸培氟沙星为主药,羟丙甲纤维素(HPMC)、乙基纤维素(EC)等为牙栓基质,按冷压法制备复方缓释牙栓,并采用紫外分光光度法测定牙栓中药物含量。结果:所制牙栓为扁梭形淡黄色小体,有良好的弹性韧性;两药回收率均在95%-100%之间,标示量均在90%-110%之间。结论:该牙栓制备工艺简单,符合2005年版《中国药典》对栓剂的规定。质量控制方法准确。为深入研究奠定了基础。
Objective： To prepare compound omidazole and pefloxacin mesylate sustained -release periodontal suppository and establish the quality standard. Methods： The suppository wasprepared with omidazole and pefloxacin mesilate as main ingredient,and hypromellose and ethylcellulose as slow- release base material. The quality standard was established by DU. Results： The periodontal suppository was yellow, flat fusiform body, with satisfactory elasticity and ductility. The recovery rates of boty medicine were between 95% - 100%, and the marked content was between 90% - 110%. Conclusion： The preparation technique is simple, convenient and corresponds to the regular of ＂Chinese Pharmacopeia＂ on suppository. Quality control is accurate and precise in, which establishs the foundation for further research.
出处
《口腔医学研究》
CAS
CSCD
2007年第1期10-13,共4页
Journal of Oral Science Research
关键词
奥硝唑
甲磺酸培氟沙星
缓释
牙栓
Omidazole Pefloxacin mesylate Sustained - release Periodontal suppository
