摘要
目的探讨非甾体类抗炎药物（NSAIDs）诱发消化性溃疡出血的临床流行病学特点。方法回顾分析1991-2004年我院诊治的消化性溃疡出血的临床资料，并用电脑数据库处理分析。结果在694例消化性溃疡并出血患者中，26．80％近期内有服用NSAIDs史。服用NSAIDs组与未服用NSAIDs组比较，服用NSAIDs组前驱症状（腹痛、消化不良等）发生率较低（30．65％比61．42％ P〈0．01）；平均年龄较大[（44．16±13．25）岁比（35．23±11．49）岁．P〈0．05]；女性比例相对较多（26．34％比15．55％，P〈0．01）；胃溃疡比例较高（28．50％比20．67％，P〈0．01）；外科手术率无明显差别（P〉0．05）；结论NSAIDs是诱发消化性溃疡出血的一常见原因，应加强对NSAIDs胃肠毒副作用的防治。
Objective To investigate the clinical epidemiologieal features of peptic ulcer bleeding induced by nonsteroidal anti-inflammatory drugs（NSAIDs）. Methods Clinical data of peptic ulcer bleeding from 1991-2004 were retrospectively analyzed. Results Among 694 cases of peptic ulcer with bleeding,26.80% had history of taking NSAIDs recently. The NSAIDs group had little clinical ,higher average age（44.16 ＋ 13.25 ys versus 35.23 ＋ 11.49 ys ）, P〈0.05）, more female（26.34% versus 15.55%,P〈0.01） and more gastric ulcer （28.50% versus 20.67%,P〈0.01） than the non-NSAIDs group. The rate of surgical treatment did not differ significantly（P〉0.05） between groups. Conclusions NSAIDs is a common cause for inducing bleeding of peptic ulcers. More attention should be paied to prevent its side effects in gastrointestinal tract.
出处
《老年医学与保健》
CAS
2007年第1期21-22,共2页
Geriatrics & Health Care
关键词
消化性溃疡
抗炎药
非甾类
药物流行病学
Peptic,ulcer
Anti-inflammatory agents, non-steroidal
Pharmacoepidemiology
