摘要
目的:延长血浆胆红素吸附的常规治疗时间,观察吸附效率的变化,探讨血浆胆红素吸附的最佳治疗时间。方法:11例高胆红素血症患者,使用BR350型胆红素吸附柱,每次吸附治疗时间由2 h延长至3 h,分别采取吸附前后血浆,分析胆红素吸附率的变化。结果:①治疗60min、120min、180min总胆红素水平与上机前相比均有显著差异(P<0.05)。②治疗60min、120min、180min时总胆红素吸附率分别为(51.3±6.6)%、(46.9±9.9)%、(43.5±9.2)%,直接胆红素吸附率分别为(45.9±3.3)%、(40.6±5.1)%、(39.3±6.6)%。随时间延长,吸附率呈下降趋势。③治疗期间无严重不良反应。结论:①血浆胆红素吸附对高胆红素血症疗效明确,随治疗时间延长,全血总胆红素与直接胆红素水平均可持续下降。②胆红素吸附率随治疗时间延长而降低,但在治疗180 m in时仍在40%左右,仍然有相当的吸附能力,血浆胆红素吸附的最佳治疗时间应不少于3 h。
Objective：To find out the proper duration of one session in bilirubin adsorption by studying the change of ad- sorption rate in a prolonged session. Methods： BR350 adsorption column was used on 11 cases of hyperbilirubinemia during each prolonged session. Blood samples were taken just before and after adsorption column at different time points. Results： 1. Serum bilirubin level after lh, 2h, 3h of adsorption was significandy different from baseline respectively. 2. There was a downtrend of adsorption rate during the treatment, but the lowest rate was nearly 40%. 3. No severe side effects were found during treatment. Conclusion： 1. Bilirubin adsorption is an effective treatment of hyperbilirubinemia, plasma bilirubin concentration could decrease continuously during a session. 2. There is a downtrend in adsorption rate that was still above 40% even after 3 hours which meant relatively good adsorption capability. Bilirubin adsorption with BR350 should be prolonged to not less than 3 hours.
出处
《军医进修学院学报》
CAS
北大核心
2007年第1期40-41,共2页
Academic Journal of Pla Postgraduate Medical School
基金
国家自然科学基金创新研究群体项目(30121005)
关键词
血浆
胆红素
高胆红素血症
灌流
吸附
plasma, bilirubin
hyperbilirubinemia
perfusion
adsorption
