摘要
目的：探讨早期乳腺癌保乳治疗后局部复发的影响因素。方法：1988年6月～2005年6月我院304名临床1～2期早期乳腺癌患者进行了乳腺肿瘤局部切除，腋窝淋巴结清扫及术后放疗，所有肿瘤切缘均为阴性，多数患者接受了术后化疗，雌激素受体阳性者口服三苯氧胺。运用单一变量和多变量统计分析方法探讨年龄，腋窝淋巴结转移数量，肿瘤大小，雌激素孕激素受体，切缘距肿瘤距离及病理分型对局部复发的影响。结果：中位随访时间为97．2月，24名患者出现了局部复发，8年累计局部复发率为9．9％。雌激素受体阴性无论在单因素分析还是在多因素分析均与局部复发相关联，而腋窝淋巴结转移数量，肿瘤大小，切缘距肿瘤距离及病理分型与局部复发无关联。结论：年龄（小于40岁）、雌激素受体阴性是早期乳腺癌保乳治疗的局部复发的重要因素。
Objective：To analyze the recurrence factors for women with early stage breast cancer after breast conservation therapy （BCT）. Methods：Between 1988 and 2005, 304 women with early stage underwent lumpectomy, axillary lymph node dissection and definitive irradiation. Most of patients received adjuvant chemotherapy. The patients with positive estrogen hormone receptors received tamoxifen administration. The risk factors of local recurrence were estimated by univariate and multivariate analyses. Results：The median follow up was 97.2 months. 24 cases of local recurrences occurred in the period of 8 ～ 204 month foUow-up. The 8-year local recurrence rates were 9.9%. Hormone receptor（negative） was a risk factor associated with local recurrence rate. However, tumor size, the number of positive axillary nodes, margin status and pathological type were not relative to local recurrence rate. Conclusion： Age and estrogen receptor are very important predictive factors of local recurrecne for women with early stage breast cancer after breast conservation therapy（BCT）.
出处
《军医进修学院学报》
CAS
北大核心
2007年第1期17-19,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
乳房切除术
区段
乳腺肿瘤
肿瘤复发
局部
mastectomy, segmental
breast neoplasms
neoplasm recurrence, local
