摘要
目的研究中药大叶钩藤(UncariamacrophyllaWall.)非生物碱部分的化学成分。方法用硅胶柱层析分离,并用各种波谱(MS、IR、NMR)法对化合物的结构进行鉴定。结果从大叶钩藤中分离鉴定了6个化合物,其结构分别为β-谷甾醇、β-胡萝卜苷、乌苏酸、α-香树素乙酸酯、3β,6β,23-trihydroxyurs-12-en-28-oicacid、3β-hydroxyurs-12-en-27,28-dioicacid。结论大叶钩藤非生物碱部分主要含乌苏酸。α-香树素乙酸酯和3β-hydroxyurs-12-en-27,28-dioicacid为首次从该植物中获得。
Objective To analyze the chemical constituents of the non-alkaloid fraction of Uncaria macrophylla, Methods The constituents were separated and purified by silica gel chromatography and recrystalization, and their structures were identified by inflated, mass and nuclear magnetic resonance spectrometry. Results Six compounds were isolated from the non-alkaloid fraction of Uncaria macrophylla, whose structures were identified as β-sitosterol, β-daucosterol, ursolic acid, α-amyrin acetate, 3β, 6β, 23-trihydroxyurs-12-en-28-oic acid, 3β-hydroxyurs-12-en-27, and 3β-hydroxyurs-12-en-27, 28-dioic acid, respectively. Conclusions Ursolic acid is the main component in the non-alkaloid fraction of Uncaria macrophylla. α-amyrin acetate and 3β-hydroxyurs-12-en-27, 28-dioic acid are isolated and characterized for the first time from this plant.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第2期226-227,共2页
Journal of Southern Medical University
关键词
大叶钩藤
化学成分
乌苏酸
Uncaria macrophylla
chemical constituents, ursolic acid
