期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乳腺浸润性导管癌MRP、LRP表达及其与临床因子的相关分析 被引量：3

暂未订购
导出
摘要 目的探讨乳腺浸润性导管癌肺耐药相关蛋白(LRP)、多药耐药相关蛋白(MRP)的表达及其与临床因子的相关性。方法采用SP免疫组化方法对332例乳腺癌组织进行MRP、LRP、C-erbB2、P53和ER、PR表达的联合检测,并与年龄、临床分期及淋巴结转移情况进行比较研究。结果332例乳腺浸润性导管癌组织中,MRP高表达率为8.13%,在≤45岁与>45岁阳性表达率分别为3.28%和10.95%(P<0.05)。在ER(-)与ER(+)患者中MRP高表达率分别为14.19%和4.55%,两者间具有显著的负相关性(P<0.05);C-erbB2(+)与C-erbB2(-)患者中MRP高表达率分别为10.70%和4.83%,两者间具有显著的正相关性(P<0.05);PR(+)LRP高表达率66.67%,PR(-)为54.31%,两者间具有显著的负相关性(P<0.05);MRP、LRP与临床分期、淋巴结转移情况均无显著相关性(P>0.05)。结论MRP高表达可能与老年乳腺癌对化疗不敏感的特点及内分泌治疗不敏感,尤其是与三苯氧胺的治疗不敏感有关。MRP、LRP与乳腺浸润性导管癌的预后关系不大。
作者 陈前军 司徒红林 李淑艳 张蓉 任黎萍 徐飚 林毅
机构地区 广州中医药大学附属广东省中医院乳腺科
出处 《南方医科大学学报》 CAS CSCD 北大核心 2007年第1期115-116,共2页 Journal of Southern Medical University
基金 广东省中医药管理局基金(1040001A)
关键词 乳腺肿瘤 肺耐药相关蛋白 多药耐药相关蛋白 相关分析
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Endo K,Machara Y,Iehiyosbi Y,et al.Muhidrug resistanceassociated protein expression in clinical gastric carcinoma[J].Cancer,1996,77(8):1681-7.
  • 2林勇,林贤平.60例乳腺癌组织中MRP、GST-π表达及意义[J].福建医药杂志,2003,25(4):126-127. 被引量：2
  • 3Filipitis M,Suchomel RW,Dekan G,et al.MRP and MDR1 gene expression in primary breast carcinomas[J].Clin Cancer Res,1996,2:1231-7.
  • 4Nooter K,dela Riviere GB,Klijo J,et al.Multidrug resistance protein in recurrent breast cancer[J].Lancet,1997,349(9069):1885-6.
  • 5Schneider J,Gonzalez RS,Polan M,et al.Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomyer indmction chemotherapy[J].Breast Cancer Res,2001,3(3):183-5.
  • 6曲延刚,邵云霞.乳腺癌LRP,GST-π的表达研究[J].肿瘤研究与临床,2005,17(4):242-243. 被引量：2

二级参考文献14

  • 1Krishnamachary N, Ceter MS. The MRP gene associated with a non-p-glyco protein multidrug resistance encodes a 190 KD membrane bound glycoprotein. Cancer Res, 1993,53 : 3658-3661.
  • 2Zaman GIR, Flens MJ et al. The human multidrug resistanceassociated protein MRP is a plasma membrane drug-efflux. Proc Nall Acod Sci, 1994, 91 (19). 8822-8826.
  • 3Breuninger N, Panls, et al. Expression of the multidrug resistanceassociated protein in NIH/3T3 cells infers multidrug resistance associated with increastal drug efflux and altered in trucellular drug distribution. Cancer Ress, 1995, 55 (11): 5342-5347.
  • 4Daniel V. Glutathione-S-transferases: gene structure and regulation of expression. Crit Rev Biochem Mol Biol, 1993, 28(3): 173-270.
  • 5Benderra Z, Mojani H, et al. Evidence for functional discrimnation between leukenur cells overexpressing multidrug-resistance associated protein (MRP) and P-glycoprotein. Adn Exp Med Biol,1999, 457: 151-160.
  • 6Benderra Z, Marjanj H, et al. Characterization of H^+ ATPasedepent activity multidrug resistance-associated protein in homoharringtoxion-resistant human leukermia K562 cells.leukemia, 1998, 12 (10): 1539-1544.
  • 7Meschini S, Marra M, Calcabrini A, et al. Role of the lung resistancecerelated protein(LRP) in the drug sensitivity of cultured tumor cells [J]. Toxicol In Vitro, 1994, 54(8):1325-1327.
  • 8Scheffer R J, Broxterman H J, Scheffer G L, et al. Overepression of a Mr 110 000 rescular protein in non- P- glocoprotein mediated multidrug resistance[J]. Cancer Res, 1993, 53(7):1475-1476.
  • 9Schneider J, Gonzalez Roces S, Polan M, et al. Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after indruction chemotherapy[J].Breast Cancer Res, 2001, 3(3):183-185.
  • 10Pohl G, Fillpits M, Suchmel R, et al. Expression of lung resistance protein(LRP) in primary breast cancer[J]. Anticancer Res, 1999, 19:5051-5053.

共引文献2

同被引文献36

  • 1李建辉,侯东祥,郭党学,王茁,毛中鹏,王振江.MRP和LRP的表达与食管鳞癌临床病理特征的关系[J].西安交通大学学报（医学版）,2005,26(4):377-380. 被引量：6
  • 2张晓丽,曹国宪,俞惠新,金坚.延胡索乙素对人乳腺癌细胞MCF-7摄取~99Tc^m-MIBI的影响[J].中华核医学杂志,2006,26(5):313-313. 被引量：11
  • 3陆锦龙,毛志福,林辉,陶仲强,刘时才.鼻咽癌组织中P-gp、MRP和LRP的表达及其临床意义[J].实用癌症杂志,2007,22(1):41-43. 被引量：6
  • 4刘红,赵晓亮,郎荣刚.原发性双侧乳腺癌P-gp LRP的表达及其与预后相关性的研究[J].中国肿瘤临床,2007,34(7):385-387. 被引量：6
  • 5Henschke CI, Shaham D, Farooqi A, et al. Computerized tomography screening for lung cancer: new findings and diagnostic work-up [ J ]. Kyobu Geka, 2004, 57(1): 4-8.
  • 6Bom HS, Kim YC, Song HC, et al. Technetium 99mTc-MIBI uptake in small cell lung cancer[J]. Nucl Med, 1998, 39(1): 91-4.
  • 7AK I, Gulbas Z, Ocak S, et al. ^99mTc-MIBI SPECT imaging in patients with lung carcinoma: is it a functional probe ofmultigrug resistance genes [ J ] ? Comput Assist Tomogr, 2007, 31 (5): 795-9.
  • 8Mistry P, Stewart AJ, Dangerfield w, et al. In vitro and in vivo characterization of XRⅡ 1576, abnoved, orally active, dual inhibitor of topoisomerase Ⅰ and Ⅱ[J]. Antieancer Drugs, 2002, 13(1): 15-28.
  • 9Vergotel, Moretti JL, Kouyoundjian JC, et al. MRPI modulation PAK-104P: detection with tmhnetitan-99m-MIBI in cultured lung ttamr cels[J]. Anticancer Res, 2002, 22(1A): 251-6.
  • 10Hendrikse NH, Kuipers F, Meijer C, et al. In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein Cancer [J]. Chemother Phamacol, 2004, 54(2): 131-8.

引证文献3

二级引证文献15

南方医科大学学报
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部