摘要
目的探讨雌激素在引产患者中预防产后出血及缩短产程中的临床治疗效果。方法选择医学原因终止妊娠病例320例,随机分为实验组175例和对照组145例。实验组患者在羊膜腔注射利凡诺前1天开始口服已烯雌酚3mg,3次/d,至排胎;对照组排胎前不给予雌激素类药物。两组均用容积法及称重法计算产后出血量,计算注药至宫缩发动及出胎时间。结果(1)胎儿娩出后2h出血量比较:实验组出血量(123.3±81.8)ml,对照组(206.3±114.4)ml,实验组产后出血例数2例,明显低于对照组的10例,差异均有显著性。(2)实验组注药至宫缩发动时间为(31±11)h,对照组为(33±12)h,差异无显著性。实验组总产程时间(6.03±3.19)h,明显低于对照组的(9.7±5.9)h,差异有显著性。(3)两组产妇未出现明显副作用。结论雌激素在引产患者产前给予,可提高子宫收缩敏感性,起到预防产后出血、减少产后出血量、缩短引产产程的作用,具有临床应用价值。
Objective To investigate the clinical efficacy of estrogen in preventing postpartum hemorrhage and shortening the birth process during induced abortion, Methods Totally 320 puerperants for termination of pregnancy for medical reasons were randomly assigned into 2 groups, the estrogen group （n=175） and the control group （n=145）, and the former were given oral estrostilben 3 mg thrice a day from the day before acrinol injection to the end of delivery. The amount of blood loss 2 h after delivery, cases of postpartum hemorrhage, and the duration of total birth process were recorded. Results Significant differences were noted in blood loss 2 h after delivery between estrodiol and control groups （123.3±81.8 vs 206.3±114.4 ml）. Two cases of postpartum hemorrhage were found in estrogen group and 10 in control group. The duration from acrinol injection to delivery was similar between the two groups （31 ± 11 vs 33± 12 h）, but the former had significant shorter duration from contraction onset to delivery than the latter （6.03±3.19 vs 9.7±5.9 h）. No side-effects were found in either group. Conclusion Estrogen given before delivery can be effective in stimulating uterine contraction for preventing postpartum hemorrhage and shortening the birth process in women undergoing induced abortion.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第1期92-93,97,共3页
Journal of Southern Medical University
关键词
产后出血
雌激素
己烯雌酚
引产
postpartum hemorrhage
estrogen
estrostilben
medical termination
