摘要
利用捆扎大鼠四肢固定头部后淹水制成应激模型，观察大鼠在应激时不同脑区Ｃａ２＋－ＡＴＰａｓｅ和ＧＳＨ－ｐｘ活性的改变。结果显示Ｃａ２＋－ＡＴＰａｓｅ和ＧＳＨ－ｐｘ活性都有显著增加，Ｃａ２＋－ＡＴＰａｓｅ活性增加高峰的出现在丘脑、下丘脑（１ｈ）先于大脑皮层和海马（２ｈ），而ＧＳＨ－ｐｘ活性的增加，大脑皮层与海马较之丘脑、下丘脑更为显著和持久。提示，在应激状态下，清除自由基的能力和清除细胞内Ｃａ２＋的能力都有所增加。
Using the stress model of bound and soaked rat,we observed the changes of Ca2+ -ATPase and GSH-px activity in different regions of rat brain. The results showed that the activity of Ca12+-ATPase and GSH-px increased remarkably;the activity of Ca2+-ATPase increased in thalamus and hypothalamus(1h) before hippocampus and cerebral cort x(2h);the activity of GSH-px increased more remarkably and lastingly in hippocampus and cerebral cortex than in thalamns and hypothalamus. This indicates the action of free radical-clearing and calcium-clearing was enhanced in the rats under stress.
出处
《镇江医学院学报》
1996年第4期311-312,共2页
Journal of Zhenjiang Medical College
