摘要
目的评价帕珠沙星的体外抗菌活性。方法采用琼脂二倍稀释法,测定帕珠沙星与左氧氟沙星对342株临床分离菌株的最低抑菌浓度(MIC)。结果帕珠沙星对革兰阴性菌和革兰阳性菌的MIC90分别为0.06-4和1-16μg/ml。对大肠埃希菌、阴沟肠杆菌、变形菌、铜绿假单胞菌、不动杆菌和链球菌的MIC90为0.06-4μg/ml,是左氧氟沙星的1/2-1/8;对肺炎克雷伯菌、金葡菌和表葡菌与左氧氟沙星抗菌作用相当,MIC90分别为0.5、1、1μg/ml;对流感嗜血杆菌、黏膜炎莫拉菌和粪肠球菌的MIC90为0.5、1、16μg/ml,高于左氧氟沙星(0.25、0.5、8μg/ml)。结论帕珠沙星对革兰阴性菌和革兰阳性菌均具有广谱的抗菌作用,对革兰阴性菌的抗菌活性优于革兰阳性菌。
Objective To evaluate in vitro antibacterial activity of pazufloxacin. Methods The minimum inhibitory concentration （MIC） of pazufloxacin and levofloxacin against 342 clinical isolates was determined by agar dilution method. Result MIC90s of pazufloxacin were 0.06-4μg/ml and 1-16μg/ml respectively against Gram-negative and Gram-positive bacteria. MIC90s of pazufloxacin were 0.06- 4μg/ml against Escherichia coli, Enterobacter cloacae, Proteus spp., Pseudornonas aeruginosa, Acinetobacter spp., and Streptococcus spp. , and those were 1/2-1/8 MIC90s of levofloxacin. MIC90s of pazufloxacin were equal to those of levofloxacin against Klebsiella peurnoniae, Staphylococcus aureus, and S. epiderrnidis. They were 0.5, 1 and 1μg/ml respectively. MIC90s of pazufloxacin （0.5, 1 and 16μg/ml） were higher than those of levofloxacin （0.25, 0.5 and 8μg/ml） agaist Haemophilus influenzae, Moraxella catarrhalis, and Enterococus faecalis. Conclusion Pazufloxacin has a broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Antibacterial activity of pazufloxacin against Gram-negative bacteria is superior to Gram-positive bacteria.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2007年第2期117-119,共3页
Chinese Journal of Antibiotics
关键词
帕珠沙星
左氧氟沙星
体外抗菌活性
Pazufloxacin
Levofloxacin
In vitro antibacterial activity
