摘要
目的比较不同类型胆石症患者与正常人肠道黏膜通透性的差异。方法根据术中结石剖面结构,将56例胆石症患者分为胆固醇结石组(n=15)和胆色素结石组(n=41),17例健康志愿者作为对照组,采用口服 ^(99)T_c^m-DTPA 的方法比较3组24 h 尿液中^(99)T_c^m-DTPA 排泄率,即肠道黏膜通透性。结果对照组24 h 尿液中^(99)T_c^m-DTPA 排泄率为4.5%±3.4%,胆固醇结石组5.0%±3.6%,胆色素结石组10.5%±6.9%,胆色素结石组尿液^(99)T_c^m-DTPA 排泄率明显高于对照组(F 值7.62,P<0.05),但胆固醇结石组与对照组比较,差异无统计学意义(F 值2.16,P>0.05)。结论胆色素结石患者肠黏膜通透性显著高于对照组,肠黏膜通透性增加可能是胆色素结石的一个发病原因。
Objective To investigate the intestinal permeability of patients with cholelithiasis of different types. Methods Technetium-99m-diethylenetriaminepentaacetatic acid （^99mTc- DTPA） at the dose of 185 MBq （5 mCi） was administered orally to 56 patients of cholelithiasis, 15 cases of cholesterol stone （ CS group ） and 41 cases of pigment stone （ PS group） based on the cross section of the stone during operation, and 17 healthy controls. A 24 h urine collection was obtained after the ingestion of the tracer to calculate the urinary excretion of DTPA. Results The mean percentage of the total ingested dose of ^99mTc- DTPA excreted in a 24 h urinary excretion was 5.0% ± 3.6% in the CS group, not significantly different from that in the control group （4. 5% ± 3.4%. F = 2. 18 ,P 〉 0.05 ）, and the mean percentage of the total ingested dose of ^99mTc- DTPA excreted in a 24 h urinary excretion of the PS group was 10. 5% ± 6. 9%, significantly higher than that in the control group （F =7.62,P 〈0. 05）, showing a significantly increase of intestinal permeability（ P 〈 0. 05 ）. Conclusion The intestinal permeability of the patients of pigment stone is higher than that of the healthy subjects. Hyperpermeability may be a factor of the pathogenesis of pigment stone.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2007年第7期464-467,共4页
National Medical Journal of China
关键词
胆结石
毛细血管通透性
^99TC^M
Cholelithiasis
Capillary permeability
Technetium Tc 99m pentetate
