摘要
目的 了解汉族人群抑郁症患者自杀未遂的环境危险因素、色氨酸羟化酶2（TPH2）基因rs7305115单核苷酸多态性与自杀未遂有无关联。方法采用配对病例对照研究，对215例自杀未遂者（男性92例、女性123例）与相应对照（与病例同性别、年龄相差3岁以内、同地区）进行TPH2 rs7305115基因型测定、自杀行为干预研究量表调查环境因素与抑郁症自杀未遂的关系研究。结果研究组与对照组在TPH2 rs7305115基因型、基因频率的差异有统计学意义（P〈0．001）；多因素条件logistic回归模型分析显示，绝望、负性生活事件、有自杀家族史，均为抑郁症自杀未遂危险因素，OR值分别为7．68（95％CI：5．79～13．74）、6．64（95％CI：2．48～11．04）、2．98（95％CI：1．17～5．04）；TPH2 rs7305115A／A为抑郁症自杀未遂的保护因素0．33（95％CJ：0．22～0．99）。结论绝望、负性生活事件、自杀家族史是抑郁症自杀未遂的危险因素，TPH2 rs7305115A／A可能是抑郁症自杀行为的保护因素。
Objective To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism（SNP） of TPH2 gene rs7305115 associated to attempted suicide in major depression. Methods Paired case-control study on 215 suicide attempters with major depression （92 male, 123 female） and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP,interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender, similar age （no more than 3 years） and from the same district. Results There were remarkably significant differences in gene types and gene frequency between case and control groups（P〈0.001 ）. Data from multivariate conditional logistic regression model analysis showed that hopelessness, negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 （95% CI：0.22-0.99） ,7.68 （95% CI：5.79-13.74）,6.64（95% CI： 2.48- 11.04）,2.98 （95% CI： 1.17- 5.04） respectively. There was no first level interaction between any of the two risk factors. Conclusion Results from the study supported the idea that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in major depression while TPH2 gene rs7305115 A/A might be the protective factor.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2007年第2期131-135,共5页
Chinese Journal of Epidemiology
基金
基金项目：江苏省“333工程”基金资助项目.
