摘要
探讨药物性肝病的临床特点及致病药物。采用回顾性分析对109例药物性肝病住院患者的用药史、临床表现、肝功能检查以及治疗转归作出综合判断。多种药物可引起肝损害，中药占51．4％（56／109），以治疗皮肤病及骨关节系统疾病的药物为主。西药占48．6％（53／109），居前三位的依次为解热镇痛消炎药、抗结核药、抗甲状腺药。女性（56.9％）多于男性（43．1％），潜伏期1—8周为主。最常见的临床类型为肝细胞损害型。重视药物性肝病的预防、诊断、治疗，高度重视中药所致的药物性肝病。
To investigate the clinical characteristics of patients with drug - induced liver disease and drugs resulting in the liver injuries. The medication taking history, clinical manifestation, liver function test and prognosis were analyzed comprehensively with retrospective review. Many drugs could induce liver disease. The traditional Chinese medicine accounted for 51.4% （56/109）. Among them, the drugs treating for skin disease and the bone joint system disease were the predomi- mint. The western medicine accounted for 48. 6% （53/109）, among which the most chief drugs were anti - inflammatory, antipyretic, antituberculotic and antithyroid drugs. The number of female patients （56. 9% ） was more than the male patients （43. 1% ）. The latent period varied 1 - 8 weeks. The most frequent clinical type was the hepatocellular damage type. The importance of the prevention, diagnosis and therapy of the disease should be emphasized, especially the disease which was induced by traditional Chinese medicine.
出处
《临床肝胆病杂志》
CAS
2007年第1期40-41,共2页
Journal of Clinical Hepatology
关键词
药物性肝病
药物
肝炎
综合分析
drug - induced liver disease
drugs
hepatitis
comprehensive analysis
