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RNAi逆转肿瘤多药耐药的研究进展 被引量：2

Advance in the study of reversing multidrug resistance by RNAi
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摘要 RNA干扰是真核生物中普遍存在的一种自然现象,利用双链RNA(double-stranded RNA,dsRNA)诱发宿主细胞同源mRNA降解,从而抑制特异目的基因表达。恶性肿瘤的多药耐药(multidrug resistance,MDR)是恶性肿瘤化疗失败的主要原因。本文以恶性肿瘤多药耐药机制的阐述为线索,综述了RNAi技术在逆转肿瘤多药耐药的研究进展。 RNAi is a very common phenomenon in eucaryon. Double-stranded RNA （dsRNA） can be used to induce degradation of homologous mRNA in the host cell and then suppression of specific gene expression. Multidrug resistance （MDR） against anticancer drugs is one of the major problems in terms of chemotherapy failure. In this review, we summarized the advance in the area how multidrug resistance against anticancer drugs is reversed by RNAi.
作者 张艳红 吴晴
机构地区 上海交通大学附属上海市第一人民医院肿瘤科
出处 《中国癌症杂志》 CAS CSCD 2007年第2期160-164,共5页 China Oncology
基金 上海市科委重点项目资助(编号:044119661)
关键词 RNAI 多药耐药 化疗 RNAi muhidrug resistance chemotherapv
分类号 R730.53 [医药卫生—肿瘤]
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参考文献20

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同被引文献11

  • 1王克芳,冯捷,昌晓红,程洪艳,成夜霞,郭慧方,付天云,崔恒.RNA干扰技术抑制卵巢癌细胞系SKOV3.ip1细胞内Her-2/neu基因表达的研究[J].中国妇产科临床杂志,2006,7(3):199-202. 被引量：2
  • 2柳英兰.卵巢上皮癌组织中HMGA1的表达及其意义[J].现代肿瘤医学,2007,15(4):538-540. 被引量：6
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  • 6Bookman MA, Darey KM, Clarke-pearson D, et al. Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase Ⅱ trial of the Gynecologic Oncology Group. J Clin Oncol, 2003,21:283-290.
  • 7Kauraniemi P, Kallioniemi A. Activation of multiple cancerassociated genes at the ERBB2 amplicon in breast cancer. Endocr Relat Cancer, 2006,13:39-49.
  • 8Yu D, Wolf JK, Scanlon M, et al. Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A. Cancer Res, 1993,53:891-898.
  • 9Bai F, Feng J, Cheng Y, et al. Analysis of gene expression patterns of ovarian cancer cell lines with different metastatic potentials. Int J Gynecol Cancer, 2006, 16:202-209.
  • 10柳英兰.siRNA对卵巢上皮癌细胞HMGA1基因表达抑制的实验研究[J].现代肿瘤医学,2008,16(7):1079-1082. 被引量：2

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中国癌症杂志
2007年 第2期

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