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ATP敏感钾通道的结构、功能及其调制 被引量：5

Structure,Function and Modulation of KATP Channels
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摘要 ATP敏感钾通道(KATP channel)的一个重要的特点就是受内源性ATP的强烈抑制,从而将细胞的新陈代谢状态与其兴奋性偶联起来,执行重要的生理功能,其调控机制非常复杂。目前尤以ATP/ADP、磷脂、细胞骨架对其的调控研究最为活跃。通过对KATP通道的结构、功能、调节机制,重点是对通道活动、敏感性及通道的衰减与复活等调控机制的最新研究进展的总结,有利于对各种与KATP有关的疾病的发病机制和临床防治做进一步的研究。 The adenosine triphosphate-sensitive potassium channels, termed KATP channels, are characterized by a strong inhibition of channel activity by intracellular adenosine 5＇-triphosphate （ATP） thereby coupling the metabolic state of cells to their excitability and regulating a variety of functions. Its regulation is very complicated. Currently, its modulation by ATP/ADP, phospholipids and cytoskeleton are being actively studied. This article reviews the advances in the structure, functlon, regulation of KATP, especially the activity, sensitivity and rundown/reactivation of the channel to provide useful information for the research on the control of KATP-related diseases.
作者 段燕红 陈付学
机构地区 上海大学生命科学学院
出处 《医学分子生物学杂志》 CAS CSCD 2007年第1期54-58,共5页 Journal of Medical Molecular Biology
基金 国家重点基础研究发展规划(973规划)(No.2006cb500801)~~
关键词 ATP敏感钾通道 结构功能分布 调节机制 KATP, structure and function, modulation
分类号 Q7 [生物学—分子生物学]
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参考文献35

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同被引文献68

  • 1高敏,王玉,汪海.埃他卡林等三种结构类型的钾通道开放剂对非血管平滑肌舒张作用的选择性[J].中国临床药理学与治疗学,2005,10(6):633-636. 被引量：5
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  • 3Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels [J].Endoer Rev, 1999,20:101-135.
  • 4Sawada K, Morishige K, Hashimoto K, Tasaka K, Kurachi H, Murata Y, et al. Gestational change of K^+ channel opener effect is correlated with the expression of uterine KATP channel subunits[J]. Eur J Obstet Gynecol Reprod Biol, 2005,122 : 49-56.
  • 5Curley M, Cairn M T, Friel A M, McMeel O M, Morrison J J, Smith T J. Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium[J]. Mol Hum Reprod,2002,8 : 941-945.
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  • 8Khan R N, Matharoo-Ball B, Arulkumaran S, Ashford M L. Po tassium channels in the human myometrium[J].Exp Physiol, 2001,86 : 255-264.
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  • 10Longo M,Jain V, Vedernikov Y P, Hankins G D, Garfield R E, Saade G R. Effects of L-type Ca^2+ channel blockade, KATP^+ channel opening and nitric oxide on human uterine contractility in relation to gestational age and labour[J].Mol Hum Reprod, 2003,9 :159-164.

引证文献5

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医学分子生物学杂志
2007年 第1期

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