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GAD-Ab、ICA联合检测在成人隐匿性自身免疫性糖尿病中的意义 被引量:1

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摘要 目的探讨成人隐匿性自身免疫性糖尿病(LADA)的早期诊断,以及谷氨酸脱羧酶抗体(GAD-Ab)、胰岛细胞抗体(ICA)对胰岛功能的影响。方法检测154例初诊的糖尿病患者的GAD-Ab和ICA,分析临床特征与抗体的相关性,并随访观察C肽水平的变化。结果GAD-Ab阳性25例(16.2%),ICA阳性27例(17.5%),单抗体阳性18例(11.7%),双抗体阳性17例(11.0%)。抗体阴性组与抗体阳性组在发病年龄、体重指数(BMI)等临床特征方面无显著性差异。随访2.5年,两组的C肽水平均有所下降,抗体阳性组餐后2h的C肽水平极显著高于抗体阴性组(P<0.01)。结论发病年龄、BMI等临床特征对诊断LADA的意义不大,抗体阳性患者的胰岛储备功能恶化迅速。
作者 李莉 郭明秋
出处 《华中医学杂志》 2007年第1期35-36,共2页 Central China Medical Journal
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