摘要
目的了解徐州市乙肝疫苗纳入计划免疫后出生儿童乙肝病毒(HBV)感染状况及其原因,为采取进一步降低乙肝病毒感染的措施提供依据。方法采用整群分层随机抽样的方法,共选择1995名儿童作为研究对象,用ELISA法检测HBV-M,采用病例——对照研究分析HBsAg阳性原因。结果徐州市1998—2004年间出生儿童的HBsAg、抗-HBs、抗-HBc、HBeAg、抗-HBe阳性率分别为0.80%、50.58%、0.65%、0.70%和0.15%。其中,16例HBsAg携带者中,13例抗-HBs、HBeAg同时阳性。母亲为HBsAg阳性的子女成为HBsAg阳性的危险性是阴性母亲子女的67.67倍。结论实施乙肝疫苗计划免疫后,我市儿童乙肝病毒感染率已降到较低水平,母婴阻断失败是感染的重要原因,应加强乙肝母婴传播阻断对策的研究。
OBJCTIVE To evaluate the distribution of HBV infection markers of 1-7 years children and determine the cause for further lowing the positive rate. METHOD Cluster sampling method was used to select 1995 children, the method of ELISA was used to test the HBV-M, case-control study Was performed to analysis the cause of HBsAg positive. RESULTS The HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe positive rate in the children born among the years of 1998-2004 are 0.80%, 50.58%, 0.6.5%, 0.70%, 0.15% respectively.The children＇ s carting of HBsAg are most attributed to mother-infant transmission. CONCLUSION The HBV infection rate is much more lower in children then before after implementing programed liB vaccination. It meeds more powerful methods to control mother-infant transmission.
出处
《中国初级卫生保健》
2007年第2期63-64,共2页
Chinese Primary Health Care
关键词
HBV
乙肝疫苗
血清流行病学
母婴传播
HBV, HB vaccine, seroepidemiology, mother-infant transmission
