摘要
为确认Ａｌｌｏｘａｎ诱发糖尿病鼠与微量元素的关连，用多元分析研究了糖尿病鼠样品中微量元素，并引出对糖尿病的新见解。用ＩＣＰ－ＡＥＳ测定了Ａｌｌｏｘａｎ诱发糖尿病鼠和对照鼠的骨、心、肾、脾、肺、肝、血和毛中１９种微量和宏量元素（Ａｌ、Ａｓ、Ｂ、Ｂａ、Ｃｄ、Ｃｏ、Ｃｒ、Ｍｇ、Ｍｎ、Ｎｉ、Ｐｂ、Ｓｅ、Ｚｎ、Ｆｅ、Ｃｕ、Ｃａ、Ｓｒ、Ｔｉ、Ｖ），结果在糖尿病鼠与对照组的微量元素间呈现一些显著差异。多元分析找到一条共同相关链（Ｍｎ－Ｎｉ－Ｃｕ－Ｓｒ－Ｔｉ），血、发样相同，与样品种类无关，此链提供了关于机体的某些特殊信息。经非线性映射，各组映射象图显示出糖尿病和对照组的样品点分布在图上不同区域。
The multivariate analysis was introduced to the study of trace elements in vitro samples of diabetic subjects to ascertain the relationship between trace elements and the Alloxan-induced diabetic rats and a new perspective in the understanding of diabetes was developed.The contents of 19 kinds of elements (Al.As.B.Ba.Cd.Co.Cr.Mg.Mn.Ni.Ph.Se.Zn.Fe.Cu.Ca.Sr.Ti.V) in organs (bone, heart, kidney, spleen, lung, liver, blood,wool ) of control and Alloxan-induced diabetic rats were determined by ICP-AES. The result indicates some signiticant difference of trace elements between diseased and control subjects.By use of multivariate analysis a common correlation chain (Mn-Ni-Cu-Sr-Ti) was found, regardless of special sample as well as in blood and hair. It seems that the chain suggests some particular information of organism. After non-linear mapping, the images of different groups show that the sample points of diabetic and control group are distributed on two different areas in a plane.
出处
《广东微量元素科学》
CAS
1996年第11期44-52,共9页
Trace Elements Science
基金
国家自然科学基金
关键词
糖尿病
胰岛素依赖型
ALLOXAN
微量元素
Trace element,Non-linear mapping,Factor analysis,Alloxan-induced diabetic rat.
