摘要
传统观点认为,成体组织中的干细胞具有有限分化潜能,只能分化产生其所在组织中的某个或某些特定的细胞。近年来随着研究的深入,人们发现干细胞的分化潜能远比先前认为的更为广泛,即干细胞具有可塑性或发生横向分化的潜能。但是,许多研究者对这一观点提出了质疑。笔者对有关干细胞可塑性的不同观点作一概述,讨论在目前公认的动物模型上观察到的干细胞可塑性现象。
Traditionally, stem cells in adult tissues were believed to be restricted in their differentiation potential and limited to generate the types of cell present in the tissue in which the stem cell resides. Recently, however, many studies indicate that stem cells may display a broader differentiation potential, termed plasticity or transdifferentiation, than what was previously thought. But the validity of this understanding has been challenged by some investigators. In this review, the authors present some standpoints on stem cell plasticity and discuss some phenomena of stem cell plasticity observed on animal models those have been generally accepted currently.
出处
《中国康复理论与实践》
CSCD
2006年第12期1067-1069,共3页
Chinese Journal of Rehabilitation Theory and Practice
关键词
干细胞
可塑性
横向分化
综述
stem cells
plasticity
transdifferentiation
review
