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短暂性脑缺血发作的质子磁共振波谱研究 被引量：1

Study of ~1H MR Spectroscopy in Transient Ischemic Attacks
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摘要 目的探讨短暂性脑缺血发作(TIA)的质子磁共振波谱(1H-MRS)改变及其临床应用价值。方法分别对25例TIA患者和25例健康志愿者(正常对照组)行1H-MRS,测量两侧大脑半球半卵圆中心代谢物包括氮-乙酰天门冬氨酸(NAA)、胆碱(Cho)和肌酸(Cr)的波峰下面积,计算NAA/Cho、NAA/Cr和Cho/Cr。对TIA患者病变侧与对侧正常脑组织及正常对照组之间各代谢物比值的差异进行统计学分析。结果TIA患者病变侧半卵圆中心的NAA/Cho(1.48±0.23)、NAA/Cr(1.23±0.17)低于对侧(1.68±0.24,1.79±0.21)及正常对照组(1.66±0.24,1.78±0.17),差异有极显著性意义(P<0.01);其Cho/Cr(1.18±0.19)高于对侧(1.05±0.16)及正常对照组(1.04±0.12),差异有显著性意义(P<0.05)。结论1H-MRS能够早期发现TIA患者的脑代谢异常,对临床诊断和治疗具有重要价值。 Objective：Using ^1H magnetic resonance spectroscopy imaging （^1H-MRSI） to investigate the cerebral metabolic changes in patients with transient ischemic attack （TIA）. Methods：^1H MRS were performed in 25 patients with TIA and 25 control subjects. Cerebral metabolism was studied by assessing the ratios of nitro-acetyl aspartate to choline （NAA/ Cho） as well as to creatine （NAA/Cr） ,and the ratio of choline to creatine （Cho/Cr） from non-affected regions in the centrum semiovale of both hemispheres. Results： In TIA patients, the NAA/Cho and NAA/Cr of the affected area （1.48±0. 23,1.23±0.17, respectively） were significantly decreased and lower than that of non-affected hemisphere （1.68±0.24, 1.79±0.21 ,respectively） as well as the control subjects （1.66±0. 24,1. 78±0. 17, respectively） with significant statistic difference （P〈0.01）. The Cho/Cr of the affected hemisphere （1.18±0. 19） was significantly increased and higher than that of the non-affected hemisphere （1.05±0.16） and control subjects （1.04±0.12） ,with statistic difference（P〈0.05）. Conclusion：Abnormal cerebral metabolic changes in patients with TIA could be demonstrated by ^1H-MRSI.
作者 卢洁 李坤成 张苗 王默力 宋宏杰 王志群
机构地区 首都医科大学宣武医院医学影像学部放射科 首都医科大学宣武医院神经内科
出处 《放射学实践》 2007年第2期136-139,共4页 Radiologic Practice
基金 北京市优秀人才培养资助项目(20042D0501809)
关键词 磁共振成像 磁共振波谱学 脑缺血 短暂性 Magnetic resonance imaging, Magnetic resonance spectroscopy Cerebral ischemia,transient
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献11

  • 1Daffertshofer M,Mielke O,Pullwitt A,et al.Transient Ischemic Attacks are more than "Ministrokes"[J].Stroke,2004,35 (11):2453-2458.
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二级参考文献24

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共引文献19

同被引文献11

  • 1Rafael Lozano,Mohsen Naghavi,Kyle Foreman,Stephen Lim,Kenji Shibuya,Victor Aboyans,Jerry Abraham,Timothy Adair,Rakesh Aggarwal,Stephanie Y Ahn,Mohammad A AlMazroa,Miriam Alvarado,H Ross Anderson,Laurie M Anderson,Kathryn G Andrews,Charles Atkinson,Larry M Baddour,Suzanne Barker-Collo,David H Bartels,Michelle L Bell,Emelia J Benjamin,Derrick Bennett,Kavi Bhalla,Boris Bikbov,Aref Bin Abdulhak,Gretchen Birbeck,Fiona Blyth,Ian Bolliger,Soufiane Boufous,Chiara Bucello,Michael Burch.??Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010(J)The Lancet . 2012 (9859)
  • 2Kiyohara T,Kamouchi M,Kumai Y,et al.ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short-and long-term risks of stroke after transient ischemic attack. Stroke . 2014
  • 3Robertus H.C. Bisschops,L. J. Kappelle,Willem P.T.M. Mali,Jeroen van der Grond.??Hemodynamic and Metabolic Changes in Transient Ischemic Attack Patients: A Magnetic Resonance Angiography and 1H-Magnetic Resonance Spectroscopy Study Performed Within 3 Days of Onset of a Transient Ischemic Attack(J)Stroke: Journal of the American Heart Association . 2002 (1)
  • 4S Claiborne Johnston,Peter M Rothwell,Mai N Nguyen-Huynh,Matthew F Giles,Jacob S Elkins,Allan L Bernstein,Stephen Sidney.??Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack(J)The Lancet . 2007 (9558)
  • 5Magnetization Transfer Imaging Shows Tissue Abnormalities in the Reversible Penumbra(J)Stroke . 2007 (12)
  • 6Annemarie D. Wijnhoud,Lisette Maasland,Hester F. Lingsma,Ewout W. Steyerberg,Peter J. Koudstaal,Diederik W.J. Dippel.??Prediction of Major Vascular Events in Patients With Transient Ischemic Attack or Ischemic Stroke: A Comparison of 7 Models(J)Stroke . 2010 (10)
  • 7Miriam Brazzelli,Francesca M. Chappell,Hector Miranda,Kirsten Shuler,Martin Dennis,Peter A. G. Sandercock,Keith Muir,Joanna M. Wardlaw.??Diffusion‐weighted imaging and diagnosis of transient ischemic attack(J)Ann Neurol. . 2014 (1)
  • 8Rose Galvin,Colm Geraghty,Nicola Motterlini.Prognostic value of the ABCD(2) clinical prediction rule: a systematic review and meta-analysis. Family Practice . 2011
  • 9Vavasour Irene M,Laule Cornelia,Li David K B,Traboulsee Anthony L,MacKay Alex L.Is the magnetization transfer ratio a marker for myelin in multiple sclerosis?. Journal of magnetic resonance imaging : JMRI . 2011
  • 10Rutgers D R,Klijn C J,Kappelle L J,van der Grond J.Cerebral metabolic changes in patients with a symptomatic occlusion of the internal carotid artery: a longitudinal 1H magnetic resonance spectroscopy study. Journal of magnetic resonance imaging : JMRI . 2000

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放射学实践
2007年 第2期

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