摘要
目的：观察二氢埃托啡成瘾者的甲状腺功能、胰腺分泌及睾酮变化。方法：用放射免疫法测定１１例男性二氢埃托啡成瘾者与２９例男性海洛因成瘾者及２６例正常对照组血中ＴＳＨ，Ｔ３，Ｔ４，Ｃ肽，胰岛素及睾酮含量。结果：二氢埃托啡成瘾者与正常对照组比较，ＴＳＨ，Ｔ３下降显著（Ｐ＜０．０１）；Ｃ肽和胰岛素增加明显（Ｐ＜０．０１）；Ｔ４下降、睾酮升高，差别不显著（Ｐ＞０．０５）。二氢埃托啡组与海洛因组比较，Ｔ３下降不显著（Ｐ＞０．０５）；ＴＳＨ和Ｔ４下降显著（Ｐ＜０．０１）；Ｃ肽、胰岛素、睾酮升高显著（Ｐ＜０．０１）。结论：二氢埃托啡成瘾者垂体甲状腺功能受抑制。
AIM:To study pituitary-thyroid,pancreas,and testis functions in dihydroetorphine addicts. METHODS:Radioimmunoassay was used to determine the blood constituents in 11 male dihydroetorphine addicts,29 male heroin addicts,and 26 healthy men. RESULTS:In dihydmetorphine addicts,the blood concentrations of TSH,T3,and T4 were lower while C-peptide,insulin,and testosterone levels in blood were higher than those in healthy men and heroin addicts. CONCLUSION:The male dihydroetorphine addicts showed inhibited pituitary-thyroid functions and raised pancreatic and testicular functions.
出处
《新药与临床》
CSCD
北大核心
1996年第6期322-324,共3页
关键词
二氢埃托啡
海洛因依赖
促甲状腺素
胰岛素
睾酮
dihydroetorphine,heroin dependence,thyrotropin,triiodothyronine,thyroxine,insulin,peptides, testosterone,substance dependence
