摘要
①目的 探讨癌旁肝组织与肝癌组织发生之间的关系。②方法 用亲和组织化学的方法检测人肝癌及癌旁组织中6种凝集素受体的表达。③结果肝癌组织菜豆凝集素(PHA)、花生凝集素(PNA)、双花藕豆凝集素(DBA)、荆豆凝集素(UEA—1)受体的阳性率明显高于癌旁组织(x^2＝4.16~53.86,p均<0.01或0.05);肝癌组织西非单叶豆凝集素(BSL)、大豆凝集素(SBA)受体的阳性率与癌旁组织无明显区别(x^2=0.03,0.04,p均>0.05);散在的嗜酸性毛玻璃样肝细胞、嗜酸性细胞结节BSL,SBA受体阳性。④结论嗜酸性毛玻璃样肝细胞、嗜酸性细胞结节与肝癌细胞具有某些相同的糖结合蛋白,嗜酸性细胞结节是肝癌的癌前期病变;BSL,SBA可作为癌前病变的检测指标。
Objective To study the relationship between the perieacinomatous tissues and hepatocarcinogenesis. Method Six kinds of lectin receptors in human hepatocellular carcinoma (HCC) and its surrounding tissue were studied by the affinitive his-tochemistry technique. Result The positive rates of phasolus vulgaris agglutinin(PHA), peanut agglutinin(PNA), dolkichos bi-florus agglutinin(DBA) and ulex europaeus agglutinin(UEA) receptors in HCC were much higher than in its surrounding tissue(x2 = 4. 16~53. 86, P<0. 01,0.05); The positive rates of bandeiraea simplicifolia lectin(BSL), soybean agglutinin(SBA) receptors showed no obvious difference between HCC and its surrounding tissue (X2 = 0. 03,0. 04, P > 0. 05); The scattered acidophilic ground glass liver cells and acidophilic hyperplastic nodules were positive for BSL and SBA receptors. Conclusion The acidophilic ground glass liver cells* acidophilic nodules and HCC have the same glycobinding proteins; Acidophilic nodules are preneo-plastic lesions of HCC t BSL and SBA receptors can be used as index of preneoplastic lesions of HCC.
出处
《青岛医学院学报》
1996年第4期290-292,共3页
Acta Academiae Medicinae Qingdao Universitatis
基金
山东省科委基金资助课题[鲁科计字(1992)18号文件]
关键词
肝肿瘤
外源凝集素
受体
liver neoplasm
exogenous lectin
receptors
