摘要
目的:探讨川崎病(KD)与过敏性紫癜(HSP)发病中趋化因子干扰素诱导蛋白10(IP-10)、单核细胞趋化蛋白-1(MCP-1)和生长相关性癌基因α(Gro-α)的水平改变及临床意义。方法:采用酶联免疫吸附实验检测15例急性期KD患儿、12例HSP患儿及10名健康对照组儿童的血浆IP-10、MCP-1和Gro-α水平变化并进行比较。结果:KD组IP-10[(394.2±176.4)ng.L-1]和MCP-1[(420.5±163.4)ng.L-1]水平较HSP组IP-10[(94.8±66.4)ng.L-1]、MCP-1[(109.2±76.6)ng.L-1]和对照组IP-10[(76.4±46.5)ng.L-1]、MCP-1[(87.7±47.8)ng.L-1]水平均明显升高(P<0.05);HSP组与对照组各趋化因子水平比较差异无显著性(P>0.05);Gro-α水平3组患儿间比较差异无显著性(P>0.05)。结论:单核细胞可能在KD发病机制中促进免疫性炎症反应的发生,IP-10与MCP-1可以作为KD临床诊断的辅助指标;在HSP发病机制中可能不涉及单核细胞;中性粒细胞可能不参与KD和HSP的发病过程。
Objective To investigate the changes and clinical significances of the chemokines of interferon-T-inducible protein 10 （IP 10）, monocyte chemoattractant protein-1 （MCP-1） and growth-related oncogene-α （Gro-α） involved in pathagenesis of Kawasaki disease （KD） and Henoch-Schonlein purpura （HSP）. Methods The chemokines production of IP-10, MCP-1 and Gro-α were assayed by ELISA in 15 patients with KD, 12 patients with HSP and 10 healthy children. Results The plasma levels of IP-10 and MCP-1 were markedly elevated in KD group [ （394. 2± 176.4 ） and （420.5±163.4） ng·L^-1] compared with HSP group [ （94. 8±66.4） and （109.2±76.6） ng·L^-1] and the control group [ （76.4±46.5） and （87.7±47.8） ng ·L^-1] （all P〈0.05）. There were no differences of the levels of IP-10 and MCP-1 between HSP and control groups （ P〉0, 05）, as well as Gro-a between the three groups. Conclusion Monocyte may enhance the immune damage in KD pathogenesis, and the levels of IP-10, MCP- 1 may be important indexes for KD. Neutrophil may be not involved in pathogenesis of HSP and KD.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2007年第1期148-150,共3页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅基金资助课题(200505213)
关键词
川崎病
皮肤黏膜淋巴结综合征
过敏性紫癜
趋化因子
Kawasaki disease
mucocutaneous lymph node syndrome
Henoch-Schonlein purpura
chemokine
