摘要
目的:探讨支气管肺泡灌洗液(BALF)中3种肿瘤标志物的检测在肺癌诊断及病情评估中的价值。方法:采用电化学发光法、酶联免疫吸附法检测61例确诊的肺癌患者和42例肺良性病变患者BALF中癌胚抗原(CEA)、细胞角蛋白片断19(CYFRA21-1)及神经特异性烯醇化酶(NSE)的含量并进行分析比较。结果:肺癌患者BALF中3种肿瘤标志物的含量均明显高于肺良性病变患者(P<0.01或P<0.05);不同病理类型肺癌中,各肿瘤标志物升高的程度均有所不同,CYFRA21-1在非小细胞肺癌中升高明显,且随着TNM临床分期的升高,其含量亦明显升高。NSE则在小细胞肺癌中升高明显。结论:BALF中3种肿瘤标志物的检测在肺癌的诊断,病理类型的判定及临床分期等方面均有较高的临床价值。
Objective： To investigate the value of three tumor markers in bronchoalveolar lavage fluid （BALF） for diagnosis and evalution of disease extent in patients with lung cancer. Methods： The level of CEA, CYFRA21-1 and NSE of BALF were measured and compared in sixty-one patients with lung cancer and forty-two patients with benign lung diseases by using electric chemilluminescent and ELISA methods respectively .The results were compared and analyzed. Results： The level of all three tumor markers in BALF of the lung cancer group were much higher than those in the benign lung disease group （P 〈 0.01 or P 〈 0.05）.These tumor markers increased in different degrees among the patients in various pathological classifications.CYFRA21-1 significantly increased in non small cell lung cancer and raised with advance of TNM.NSE increased in small cell lung cancer. Conclusion： The measurement of three tumor markers in BALF has more clinical value and contribute to the diagnosis, pathological classification and clinical stages of lung cancer.
出处
《天津医药》
CAS
北大核心
2007年第1期30-32,共3页
Tianjin Medical Journal
关键词
支气管肺泡灌洗液
肿瘤标记
生物学
肺肿瘤
诊断
bronchoalveolar lavage fluid tumor markers, biological lung neoplasms diagnosis
