摘要
目的：吸入一氧化氮（ＮＯ）可特异性降低肺动脉高压，但也有使血中高铁血红蛋白（ＭｅＨｂ）浓度增高的毒副作用．作者探讨用亚甲蓝（ＭＢ）还原ＭｅＨｂ同时，能否削弱吸入ＮＯ的治疗作用．方法：用缺氧性肺动脉高压模型，观察９条犬吸入体积分数为（９０±７）×１０－６的ＮＯ降低肺动脉压时，ｉｖ２ｍｇ·ｋｇ－１ＭＢ对上述作用的影响．结果：吸入ＮＯ可显著降低肺动脉高压（Ｐ＜０．０１），ｉｖＭＢ可逆转ＮＯ作用的５０％（Ｐ＜０．０１），同时还显著增加心输出量（Ｐ＜０．０５），但上述作用仅维持５ｍｉｎ．结论：ＭＢ治疗吸入ＮＯ的毒副作用同时，可削弱ＮＯ的治疗作用，虽作用短暂（５ｍｉｎ），但临床上对严重肺动脉高压者仍应谨慎使用．
Objective: Low dose inhalation of nitric oxide could selectively decrease the pulmonary hypertension. But methemoglobin (MeHb) increasing is one of side effects. This study was to investigate whether methylene blue (MB) could attenuate the therapeutic effect of NO while reducing methemoglobin. Methods: The effect of administering MB 2 mg·kg -1 intravenously on mean pulmonary arterial pressure (MPAP) was observed, after 90±7 vpm (volume per million) NO was inhaled in 9 dogs with pulmonary hypertension induced by hypoxia (FiO 2=0.08). Results: Inhalation of NO significantly decreased MPAP ( P <0.01). Intravenous administration of MB blocked 50% pulmonary vasodilator effect of inhaled NO ( P <0.01), significantly increased cardiac output ( P <0.05). But the effects only lasted 5 min. Conclusion: Methylene blue could transiently and partly reverse the pulmonary vasodilator action of inhaled nitric oxide in canine hypoxic pulmonary hypertension mode. The MB should be carefully used in severe pulmonary hypertension.
出处
《第四军医大学学报》
1996年第5期364-367,共4页
Journal of the Fourth Military Medical University
基金
总后医药卫生回国人员科研启动基金
关键词
一氧化氮
亚甲蓝
肺动脉高压
缺氧性
nitric oxide methylene blue pulmonary hypertension dogs
