摘要
目的探讨舍曲林合并利培酮治疗精神分裂症阴性症状的疗效及安全性。方法将86例以阴性症状为主的住院精神分裂症患者随机分为研究组(舍曲林+利培酮)和对照组(利培酮+安慰剂)。在治疗前及治疗后4、8、12周,用阳性与阴性症状量表(PANSS)、不良反应量表(TESS)评定疗效和安全性。结果治疗后8、12周,两组PANSS总分、阴性因子分比较差异有统计学意义(P<0.05)。研究组阴性因子各项症状评分低于对照组,差异有统计学意义(P<0.05或P<0.01)。而两组TESS评定无统计学意义(P>0.05)。结论舍曲林合并利培酮治疗精神分裂症阴性症状安全有效,副作用少。
Objective： To study the efficacy and safty of risperidone combined with sertraline on negative symptoms of schizophrenia. Methods： 86 cases of schizophrenia with prominent negative symptoms were randomly divided into groups, With one treated with sertraline combined risperidone and the other with risperidone combined placebo. Effects and side effects were assessed with the Positive and Negative Syndrome Scale （PANSS） and Treatment Emergent Symptoms Scale （TESS） respectively before and after 4, 8, 12 week treatment. Results：After 8, 12 week treatment, the total scores of PANSS and negative symptom scale were significantly different between two groups （ P 〈 0, 05 ）. The symptom rating of negative factors were significantly different between two groups （P 〈0.05 or .P 〈0. 01 ）, But the total scores of TESS had no significantly different （P 〉 0.05 ）. Conclusion： It is suggest sertraline in combination with risperidone is effective and safe in treatment of the negative symptom in schizophrenia patient,
出处
《上海精神医学》
2006年第6期349-351,共3页
Shanghai Archives of Psychiatry
关键词
精神分裂症
阴性症状
舍曲林
利培酮
Schizophrenia Negative symptom Risperidone Scrtraliue
