摘要
赛庚啶对大鼠脑缺血再灌注损伤的保护作用粱健１王美纳杨庆余２王菁３（西安医科大学基础医学院药理学教研室，西安７１００６１）赛庚啶（ｃｙｐｒｏｈｅｐｔａｄｉｎｅ，Ｃｙｐ）为一哌啶类化合物，具有抗组胺和抗５－羟色胺作用．近年来相继发现其有抗心律失常，抗休克...
Acute cerebral ischemia reperfusion injury was produced by reversible middle artery occlusion without craniectomy in rats. Cyproheptadine (Cyp) 1.5 and 2 mg·kg -1 iv decreased the size of cerebral infarction after ischemia for 2 h followed by reperfusion for 3 h. Cyp (2 mg·kg -1 iv) improved brain electrical activity, increased the activity of superoxide dismutase, and decreased the content of malondialdehyde in brain. These results indicate that Cyp has protective effects against cerebral ischemia- reperfusion injury, probably through inhibiting free radical and subsequent lipid peroxidation.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1996年第3期235-236,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
赛庚啶
脑缺血
再灌注损伤
cyproheptadine
cerebral ischemia
reperfusion injury
cerebral infarction
superoxide dismutase
malondialdehyde
