摘要
二乙基二硫代氨基甲酸钠（ＤＤＴＣ）能明显抑制顺铂诱导鼠伤寒沙门氏菌ＴＡ１００，ＴＡ９８回变，有Ｓ９代谢活化系统时抑制作用增强，１６０．７４μｇ／ｐｌａｔｅＤＤＴＣ对０．２５～２．００μｇ／ｐｌａｔｅ顺铂抑制率为８７．４％～９５．７％（ＴＡ１００）和８９．４％～１０５．５％（ＴＡ９８）．小鼠ｉｐ顺铂１．５ｍｇ·ｋｇ－１，２４ｈ重复ｉｐ１次，每次给顺铂后１ｈｉｐＤＤＴＣ４００～８００ｍｇ·ｋｇ－１或同时ｉｇＤＤＴＣ７５０～１５００ｍｇ·ｋｇ－１．可显著降低顺铂诱发小鼠骨髓多染红细胞微核的形成．
Effect of sodium diethyldi thiocarbamate (DDTC) on the mutagenicity of cisplatin was studied by Ames test and mouse bone marrow micronucleus test. DDTC had an inhibitory effect on mutation induced by cisplatin in the indicator system of Salmonella typhimurium . When the mutation of TA100 and TA98 was induced with 0.25 2.00 μg per plate of cisplatin, the inhibitory effect increased noticeably with metabolic activation. The inhibitory rate of DDTC at 160.74 μg per plate was 87.4% 95.7% (TA100) and 89.4% 105.5% (TA98). The micronucleus formation induced by cisplatin was effectively inhibited by DDTC 400 800 mg·kg -1 ip 1 h after or 750 1500 mg·kg -1 ig simultaneously with ip cisplatin 1.5 mg·kg -1 (twice at 24 h interval). The results suggest that DDTC possesses the ability to reduce the mutagenic action of cisplatin.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1996年第3期207-210,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
顺铂
二乙基
二硫代氨基
甲酸钠
致突变试验
cisplatin
sodium diethyldithiocarbamate
Ames test
micronucleus test
mutagenicity test
