摘要
目的报道5例乳腺原发性非霍奇金淋巴瘤(PBNHL)探讨其临床病理特点、诊断和鉴别诊断。方法对5例乳腺原发性非霍奇金淋巴瘤进行光镜、免疫组化和基因重排检测。结果镜下肿瘤细胞均弥漫分布,2例瘤细胞中等大,圆形、卵圆形,胞质中等量,核大,染色质细,核仁不明显;2例瘤细胞呈空泡状,核仁明显;2例瘤细胞内可见浆细胞样淋巴细胞,5例核分裂均多见。免疫表型4例肿瘤细胞均CD20、CD79a和LCA弥漫阳性,CD3和CD45RO灶性阳性。1例仅LCA阳性,而CD20、CD79а、CD3和CD45RO均阴性。结论乳腺原发性非霍奇金淋巴瘤是一种较罕见的结外恶性淋巴瘤,诊断和鉴别诊断主要依赖其病理形态学特点并结合免疫表型。
Objective： To report five cases of primary breast non - Hodgkin＇s lymphoma and discuss its clinical, pathologic features and differential diagnosis. Methods： The histological, immunohistochemical features of the five cases and gene rearrangement of one case of primary breast non - Hodgkin＇s lymphoma were evaluated based on the review of related literature. Results： Tumor cells were round or orbicular - ovate and medium size, with moderate cytoplasm and big nuclei and unapparent nucleoli in two cases, and racuolar cytoplasm with apparent nucleoli in two cases and exhibit plasma cell - like differentiation in another two cases. Tumor cells were diffusive distribution with high frequent mitotic figures. Immunohistochemically, four cases showed diffusively immunoreactive for CD20, CD79a and LCA with scattered expressing CD3 and CD45RO. One case was only LCA positive. Gene rearrangement has been done in one ease and revealed heary chain immunoglobulin κ rearrangement. Conclusion： Primary breast non - Hodgkin＇s lymphoma is a rare tumor of the breast, morphologie characteristics and immunophenotype is the key to the correct pathologic and identifier diagnosis.
出处
《现代肿瘤医学》
CAS
2007年第2期248-251,共4页
Journal of Modern Oncology
关键词
非霍奇金淋巴瘤
免疫组化
基因重排
non - Hodgkin＇s lymphoma
immunohistoehemistry
gene arrangement
