摘要
抽提、分离、纯化不同病理类型的肺癌组织及胚胎组织中的中性糖脂（Ｎ－ＧＳＬ），行高效薄层层析（ＨＰＴＬＣ），薄层扫描确定其相对含量，结果表明，正常肺Ｎ－ＧＳＬ以三己糖神经鞘氨醇（ＣＴＨ）、单己糖神经鞘氨醇（ＣＭＨ）表达为主，肺癌组织中双己精神经鞘氨醇（ＣＤＨ）表达增加，ＣＴＨ及ＣＭＨ减少，胚胎肺ＣＴＨ的表达与肺癌ＣＴＨ的表达无明显差异，但胚胎肺组织中ＣＭＨ缺失，肺癌组织中大多出现了胚胎期表达较强的红细胞糖甙脂（Ｇｌｏｂｃｅｒ）以下的长糖链的Ｎ－ＧＳＬ；不同病理类型的肺癌组织中Ｎ－ＧＳＬ的表达有所不同。
The neutral glycosphingolipids (N-GSL) from the tissues of lung cancer, embryonic lung and normal lung was analysised. The results of high performance thin layer chromatography (HPTLC) plates showed that on lung cancer tissue there is an increased expression of ceramide dihexoside(CDH), an decreased expression of ceramide trihexoside (CTH) and ceramide monohexoside(CMH) comparison with normal lung tissue. On the embryonic lung tissue, the glycosphingolipids was mainly found to be Globcer. The expression of some neutral glycosphingolipids with long saccharides chain on tumor tissue was found to be related with the pathological type and cell differentiation of lung cancer Further analysis of this neutral glycosphingolipids might be helpful to study on carcinogenesis, differentiation and diagnosis of lung cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第4期218-220,共3页
Cancer Research on Prevention and Treatment
关键词
胚胎抗原
糖脂
肺肿瘤
Lung cancer
Neutral glycosphingolipids
Embryonic antigen
