摘要
为探讨强啡肽Ａ（ＤｙｎＡ）在脊髓损伤患者脑脊液和血液中的动态变化及临床意义，作者采用放射免疫测定法（ＲＩＡ）检测了３４例急性脊髓损伤患者脑脊液（ＣＳＦ）和血浆中强啡肽Ａ含量变化，随访６个月至１．５年，对脊髓损伤患者的神经功能恢复进行评价。结果发现：伤后４小时完全性脊髓损伤患者（ｎ＝９）ＣＳＦ和血浆中的ＤｙｎＡ含量（ｐｇ／ｍｌ）分别为：２４０．０２±２２．１７和２０２．０７±２１．５６，不完全性脊髓损伤患者（ｎ＝１６）分别为１８１．７６±２２．８９和１４０．５±２３．４４，无脊髓损伤患者（ｎ＝８）分别为７６．１３±２２．８１和３６．４８±２２．８２。结果揭示：脊髓损伤越重，ＤｙｎＡ升高越明显，恢复至正常的时间越长，预后也越差。本检测对指导急性脊髓损伤的治疗和判断预后具有一定意义。
o investigate the changes and significance of Dynorphin A in cerebral spinal fluid andplasma in patients following acute spinal cord injury. Changes of Dynorphin A in cerebralspinal fluid and plasma in 34 patients following acute spinal cord injury was measured by ra-dioimmunoassary,Within 4 hours of injury,Dynorphin A in patients(n=9)with completespinal cord injury was 240.02±22.17 in CSF and 202.07±21.56 in plasma;Dynorphin A inpatients with incomplete spinal cord injuring patients(n=16) was 181.76 ± 22.89 in CSFand 140.5±23.34 in plasma,In patients(n=8)without spinal cord injury,Dynorphin Awas 88.83±22.92 in CSF and 47.33±20.75 in plasma. In control group(n=10),the corre-sponding values were 76.13±22.81 and 36.48±22.82.The results showed that the moreseverely the spinal cord was injured,the more markedly Dynorphin A increased,the longertime it took for Dynorphin A to return to normal,the worse the prognosis. These findingsindicated that measurement of Dynorphin A is of value in the treatment of spinal cord injuryand in the assessment of the prognosis.
出处
《上海医学》
CAS
CSCD
北大核心
1996年第12期683-686,共4页
Shanghai Medical Journal
基金
国家自然科学基金
