摘要
目的研究番茄红素(lycopene,LP)对高脂血症大鼠血脂、血凝及纤溶的影响。方法建立大鼠的高脂血症模型,同时连续ig给予LP(20 mg/kg)或空白溶媒30 d,测定大鼠血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、凝血酶原时间(prothromb in tim e,PT)、活化部分凝血活酶时间(activated partialthrombp lastin tim e,APTT)、组织型纤溶酶原激活物(tissue p lasm inogen activator,t-PA)活性及纤溶酶原激活物抑制剂1(p lasm inogen activator inh ib itor1,PAI-1)活性。结果与饲HFD组比较,饲HFD大鼠在连续ig给予LP(20 mg/kg)30 d后,大鼠血浆TG含量平均下降27%,TC含量平均下降21%,LDL-C含量平均下降39%,HDL-C含量平均增加24%;血浆APTT显著延长而PAI-1活性降低(P<0.05),t-PA活性显著增加(P<0.01)。结论番茄红素不但能有效降低高脂血症大鼠血脂,而且可能通过防止脂质过氧化而有效改善动物血凝系统。
Objective To explore the effects of lycopene （LP） on lipidemia, blood coagulation and fibrinolysis in experimental hyperlipidemia rats. Methods Experimental hyperlipidemia rats were i.g. administration of LP （20 ml · kg^-1 · d^-1 ） or vehicle （ 0.5% CMC, 10 ml · kg^-1 · d^-1 ） for 30 d. The levels of plasma triglyceride （TG）, total cholesterol （TC） , high density lipoprorein cholesterol （ HDL-C）, low density lipoprotein cholesterol （ LDL-C）, prothrombin time （ PT）, activated partial thrombplastin time （ APTT）, plasminogen activator inhibitor 1 （ PAI-1 ） activity and tissue plasminogen activator （t-PA） activity were measured. Results Plasma TG and HDL- C of the rats fed high fat diet （HFD） and dosed LP （20 mg/kg · d） was 27% lower and 24% higher than that of the HFD group rats. The APTT of LP and HFD group rats were significantly longer than that of the HFD group （ P 〈 0.05 ）. The PAI-1 in LP and HFD group was higher （P 〈 0.05 ） and the t-PA in LP and HFD group was lower than that of the HFD group （P 〈 0.01 ）. Conclusion Blood clotting system in experimental hyperlipidcmia rats was improved by i. g. administration of LP. The results from the experiments may be helpful for the use of LP as an anti-atherogenesis drug.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第1期88-89,共2页
Lishizhen Medicine and Materia Medica Research
关键词
番茄红素
高脂血症
血凝
纤维蛋白溶解
Lycopene
Hyperlipidemia
Blood Coagulation
Fibrinolysis Activity
