摘要
隐孢子虫病是一种重要的人兽共患的原虫病,目前尚无用于治疗隐孢子虫病的特效药物。线粒体是真核生物中拥有蛋白和酶最多的细胞器,因而隐孢子虫线粒体也可能成为药物潜在的作用靶位。最近一些研究表明隐孢子虫存在线粒体诱生的细胞器,但和其他原生动物的线粒体存在着差异。隐孢子虫具有退化的线粒体,但缺少线粒体基因组,完全依赖核基因来编码所需的功能蛋白。本文对隐孢子虫线粒体存在的依据及其可能具有的功能作一综述。
Cryptosporidiosis is an important apicomplexan disease with medical and veterinary significance. There is still no effective drug for its control. Mitochondrion is an organelle which contains most protein and enzyme in eukaryotes, so the mitochondrion of Cryptosporidium may be a potential target of drugs. Recent studies provided evidence for a mitochondrial derived compartment in this parasite. But the organelle has some difference to that of other apicomplexan parasites. This organelle appears to lack its genome, and thus must be entirely dependent on nuclear-encoded proteins. This article reviews the evidence for the organelle in Cryptosporidium and its probable function.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2006年第6期461-465,共5页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
隐孢子虫
线粒体
Cryptosporidium
Mitochondrion
