摘要
目的为了揭示临床实验室乙型肝炎病毒血清标志物少(罕)见模式客观存在的规律,探讨和分析了乙型肝炎病毒血清标志物全阳性模式病例的临床转归情况以及血清标志物的动态变化趋势。方法以慢性乙型病毒性肝炎患者为对象,用荧光定量PCR和酶联免疫吸附试验同步检测不同时段血清HBVDNA和HBsAg、HBsAb、HBeAg、HBeAb、HBcAb五项血清学标志物,并进行血清肝功能酶学指标的动态跟踪。结果在长达3个月的时间段内,HBVM持续稳定在全阳性模式不变,用重组人干扰素α2b(安福隆)进行抗病毒治疗的早期应答虽不明显,但治疗至5个月后,随着病毒的阴转,HBeAg和HBeAb也逐步阴转,肝功能酶学指标逐步恢复正常,但HBsAg与HBsAb仍同时保留阳性。结论HBVM在慢性乙型肝炎患者不同病程中可呈现不同模式的组合,而不能简单的用“大三阳”、“小三阳”或15阳性等模式进行解释,应动态观察乙肝两对半组合模式以及编码的变化,有利于对乙型肝炎的诊治和疗效评估。
Objective To unveil infrequent pattern of hepatitis B virus serologic markers （HBVM）, the clinical pass and dynamic change trend were analyzed from the patient who is complete positive pattern of Hepatitis B virus serologic markers. Methods HBsAg, HBsAb, HBeAg, HBeAb, HBcAb and hepatitis B virus deoxyribonucleic acid （HBVDNA） of different period serums of patient with HBV infection were determined respectively by enzyme-linked immunoassays（ELIAS） and polymerase chain reaction（PCR）. At one time the enzymologist target of serums,ALT, AST, GGT, ALP, were determined. Results The results shows that complete positive pattern of HBVM are sustained pass three-month treatment by Recombinant Human Interferona2b, but HBeAg and HBeAb along with HBVDNA regress negative after five-month treatment. Although the enzymologist targets of serums were natural, HBsAg and HBsAb were positive. Conclusion Our research suggests that the buildup of HBVM of chronic patient were different in different course of diseases. Look into coding of HBVM are valuable for diagnosing and treatment for patient with HBV infection.
出处
《临床和实验医学杂志》
2007年第1期30-31,共2页
Journal of Clinical and Experimental Medicine
