摘要
为了解儿童系统性红斑狼疮（ＳＬＥ）及狼疮脑病（ＮＰＬＥ）时抗神经节甙抗体（ＡＧＡ）的存在及血清或脑脊液中ＡＧＡ的临床相关性。采用酶标记免疫测定法检测了４７例ＳＬＥ患儿（其中１３例临床诊断为ＮＰＬＥ）的７１份血清标本、８份脑脊液标本中的ＡＧＡ水平。结果脑脊液中的ＡＧＡ与ＮＰＬＥ有明显相关性，５例ＮＰＬＥ脑脊液中ＩｇＧ－ＡＧＡ阳性、４例ＩｇＭ－ＡＧＡ阳性。２例的纵向观察显示脑脊液中的ＡＧＡ变化与临床病程相关。提示ＡＧＡ有可能作为儿童ＮＰＬＥ诊断的重要指标之一。
Todeterminethepresenceofantigangliosideantibodies(AGA)inchildrenwithneu-ropsychiatriclupuserythematosus(NPLE)anditsassociationwithclinicalcourse,weexamined71serumsamplesand8CSFsamplesfrom47childrenwithsystemiclupuserythematosus(SLE),a-mongwhom13caseswereclinicalydiagnosedasNPLE.SignificantcorrelationwasfoundbetweenAGAincerebrospinalfluid(CSF)andNPLE.CSFspecimensofalthe5patientswithNPLEwerepositiveforIgG-AGAand4ofthemhadpositiveIgM-AGA.Alongitudinalstudyof2casesshowedthatAGAvariedwithclinicalcourses.NosignificantdiferencesinserumAGAwereseenbetweenpatientswithNPLEandthosewithoutNPLE.ThepresentstudysuggeststhatAGAmaybeoneofthemarkersforthediagnosisofNPLEinchildren.Thisresultalsosupportsthehypothesisthatin-trathecalantibodyproductionplaysanimportantroleinimmunopathologicprocessofNPLE.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1996年第6期404-406,共3页
Chinese Journal of Pediatrics
关键词
系统性红斑狼疮
神经节甙抗体
儿童
Lupuserythematosus,systemicAntigangliosideantibodiesBraindiseases
