摘要
肥大细胞与气道平滑肌相互作用在哮喘气道高反应的产生中起重要作用。肥大细胞产生多种脂类介质、趋化性细胞因子、细胞因子和酶类，它们与气道平滑肌细胞相互作用产生对收缩性刺激的高反应性和增生性，并且激活气道平滑肌细胞产生干细胞因子和其它趋化性细胞因子、细胞因子及生长因子，它们补充、分化和保持肥大细胞。哮喘气道的肥大细胞浸润是T细胞依赖的，来自T细胞及其它来源的Th2型细胞因子对循环及组织中肥大细胞前体的扩展起作用。
Interactions of mast cell and airway smooth muscle could be an important contributor to airway hyper-responsiveness in asthma. Mast cells produce a variety of lipid mediators, chemokines, cytokines and enzymes that may interact with ASM cells to cause hyper-reactivity to constrictive stimuli and proliferation, then the activated ASM can produce stem cell factor and other chemokines, cytokines, and growth factors that may act in recruitment, differentiation, and retention of mast cells. Mast cell infiltration of the airways in asthma is T-cell-dependent, and Th2 cytokines from T cells and other sources act in mast cell expansion from circulating and tissue precursors.
出处
《国际呼吸杂志》
2007年第1期56-59,共4页
International Journal of Respiration
关键词
肥大细胞
气道平滑肌
哮喘
Mast cell
Airway smooth muscle
Asthma
