摘要
分子肿瘤病理学是一门新兴的学科。它是分子生物学和肿瘤病理学相结合的产物。与传统的肿瘤病理学以形态学为基础的诊断不同,分子肿瘤病理学是从分子水平运用客观的科学证据来作出诊断。分子肿瘤病理学与传统肿瘤病理学不但相辅相成,而且能在传统肿瘤病理学的基础上进一步预测肿瘤的生物学行为及指导治疗。本综述在概述分子肿瘤病理学的基本概念和理论的基础上,运用几个真实的病例来阐明分子肿瘤病理学的临床应用及指导作用。这些例子虽然不能代表分子肿瘤病理学的方方面面,但希望能向读者说明分子肿瘤病理学在肿瘤的诊断、指导治疗、预测预后,以及预防等方面能给临床医生带来的帮助。
Molecular oncologic pathology is a relatively new discipline. It integrates molecular biology with oncologic pathology, Different from the morphology-based traditional diagnostic pathology, molecular oncologic pathology relies on molecular evidences. Complementary to and based on traditional diagnostic pathology, molecular oncologic pathology further predicts the biological behavior of a given tumor and also guides the therapy, This review elaborated the basic concepts and theories of molecular oncologic pathology. It listed several cases to illustrate the clinical applications of molecular oncologic pathology, and to explain how molecular oncologic pathology assists clinicians in cancer diagnosis, treatment, prognostication, and most importantly, cancer prevention.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第1期106-112,共7页
Chinese Journal of Cancer
基金
中山大学"百人计划"引进人才启动基金
美国"李氏基金会"2005/2006年度杰出成就奖科研基金~~
关键词
肿瘤/病理学
肿瘤/诊断
肿瘤/遗传学
生物学行为
治疗原则
预后预测
Neoplasm/pathology
Neoplasm/diagnosis
Neoplasm/genetics
Biological behavior
Neoplasm/therapy
Neoplasm/prognosis prediction
