摘要
目的:研究丹参酚酸B(salvianolicacidB,SA-B)盐对内皮素-1(endothelin-1,ET-1)致大鼠门静脉压力升高的抑制效应,并探讨其作用机制。方法:28只大鼠随机分为ET-1组、ET-1+SA-B组、ET-1+ETAR阻断剂(BQ-123)组和ET-1+ETBR阻断剂(BQ-788)组。ET-1+SA-B组大鼠给予SA-B溶液灌胃,其余3组大鼠给予饮用水灌胃,共5d;ET-1+ETAR阻断剂和ET-1+ETBR阻断剂两组于实验前30min从大鼠股静脉分别注入BQ-123和BQ-788,然后各组大鼠经股静脉以3μg/kg剂量注射ET-1溶液,观察大鼠门静脉压力、颈动脉压力和心率的变化。结果:注入ET-1后大鼠门静脉压力升高,以ET-1组升高幅度最大,预先灌服SA-B溶液或提前注入了ETR阻断剂的大鼠门静脉压力虽然也升高,但升高幅度较ET-1组显著降低。结论:SA-B在体内能够明显抑制ET-1所致的门静脉压力升高,有类似ETR阻断剂的作用。
Objective： To investigate the effects of salvianolic acid B （SA-B） on portal hypertension induced by endothelin-1 in rats.
Methods： Twenty-eight Sprague-Dawley rats were randomly divided into four groups： ET-1 group, ET-1＋SA- B group, ET-1＋ETAR blocker （BQ-123） group and ET-1＋ETBR blocker （BQ-788） group. The rats of ET-14- SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups＇ drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously.
Results： After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788.
Conclusion： SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.
出处
《中西医结合学报》
CAS
2007年第1期61-64,共4页
Journal of Chinese Integrative Medicine
基金
上海市重点学科建设资助项目(No.Y0302)
关键词
高血压
门静脉
丹参
中药
hypertension, portal
Salvia miltiorrhiza
Chinese herbal drugs
