摘要
目的:应用定量CT进行骨密度的测定,分析深圳地区正常人群随着年龄增加骨密度的变化。方法:选择2004-09/2005-03来深圳市龙岗中心医院体检的深圳地区人群(居住年限10年以上,无职业聚集性)242人,男性122人,女性120人,排除骨质疏松性骨折以及有可能引起骨质疏松的疾病者。将受试者按年龄分成20～29岁、30～39岁、40～49岁、50～59岁及60岁以上5个年龄组。用定量CT(120kV,195mA,扫描时间0.75s/层,层厚10mm)测量L1～3椎体横断面中部的松质骨结构,通过软件处理得到骨矿密度数值,同时计算骨密度10年丢失率(即上一年龄组的骨密度与本年龄组的比值)。结果:242人全部进入结果分析。①L1～3松质骨骨密度值:20～29岁、30～39岁、40～49岁、50～59岁及60岁以上年龄组男性分别为(165.35±15.61),(164.93±17.80),(153.62±20.34),(141.42±19.55),(119.78±19.65)mg/cm3,女性分别为(175.14±14.24),(174.99±15.57),(165.38±20.65),(135.38±21.39),(105.13±15.63)mg/cm3。无论男女,20～29岁和30～39岁组比较差异不显著(P>0.05),30岁以后各年龄组比均有显著性差别(P<0.05),随着年龄的增长,骨密度值逐渐降低。②不同年龄组的松质骨与皮质骨骨密度年丢失率无差异(P>0.05)。结论:骨密度值与年龄呈负相关,随着年龄的增大,骨密度的丢失导致骨质疏松。
AIM： To detect the bone mineral content （BMC） by quantitative computed tomography （QCT）, and study the changing rules of BMC with the increasing age in Shenzhen city normal people. METHODS： A total of 242 subjects （122 males and 120 females） in this research, who received healthy examinations in Longgang Central Hospital of Shenzhen City between September 2004 and March 2005, were the normal inhabitants living more than 10 years in Shenzhen district excluded osteoporotic fracture or osteoporosis. They were divided into 5 age groups： 20-29 years old group, 30-39 years old group, 40-49 years old group, 50-59 years old group, and over 60 years old group. The cancellous bone structure in the middle of L1-L3 cantrum cross-section was detected by QCT （120 kV, 195 mA, scanning for 0.75 s, and 10 mm in thickness）. The BMC value was processed by SPSS software package. Meanwhile, the loss rate of BMC in recent 10 years was calculated as the ratio of BMC between former age group and present age group. RESULTS： Totally 242 patients were involved in the result analysis.①The cancellous BMC values of males and females were （165.35±15.61）, （164.93±17.80）, （153.62±20.34）, （141.42±19.55）, （119.78±19.65） mg/cm^3 and （175.14±14.24）, （174.99 ±15.57）, （165.38 ±20.65）, （135.38 ±21.39）, （105.13 ±15.63） mg/cm^3, respectively. There was no significant difference in the BMC values between 20-29 years old group and 30-39 years old group （P 〉 0.05）, but the BMC values differed obviously among over 30 years old groups （P 〈 0.05）. BMC decreased gradually with the age increased.②The loss rate of BMC value was similar between cancellous bone and cortical bone （P ~ 0.05）. CONCLUSION： BMC value is negatively related to the age, with the age increases, BMC decreases, which may induce osteoporosis.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第17期3222-3224,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
深圳市医学重点专科基金
深圳市龙岗区科研基金支持项目(200306)~~
