摘要
AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved.
AIM： To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines.METHODS： A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals.RESULTS： One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients （63%）, of whom 40 （51%） had a prior diagnosis of cirrhosis and 25 （32%） had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients （37%）. The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers for early vasoactive drug administration （87% of cases）, association with ligation （42%） more often than sclerosis （21%） at initial endoscopy, and antibiotic prophylaxis （64%）. By contrast, prescription of beta-blockade alone or in combination （0 to 100%, P = 0.003） for secondary prophylaxis and lactulose （26% to 86%, P = 0.04）, differed among centers.CONCLUSION： In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved.
基金
Supported by grants from the French Society of Gastroenterology
