摘要
目的:观察复方甘草酸苷治疗药物性肝病的疗效。方法:60例药物性肝病患者随机均分为治疗组与对照组。在使用维生素、氨基酸等药物常规治疗的基础上,治疗组将复方甘草酸苷注射液60mL溶于5％葡萄糖注射液250mL中静脉滴注,1次·d-1,疗程4wk;对照组将还原型谷胱甘肽1 200mg溶于5％葡萄糖注射液250mL中静脉滴注,1次·d-1,疗程4wk。结果:治疗组与对照组的总有效率分别为96．7％、93．3％(P<0．05);治疗组有2例出现轻度头痛,对照组有1例出现轻度头晕,均经对症治疗后好转,无需减量或停药。结论:复方甘草酸苷治疗药物性肝病的疗效与还原型谷胱甘肽相当。
OBJECTIVE：To investigate the therapeutic effect of Stronger Neo-Minophagen C（SNMC） on drug-induced liver disease.METHODS： 60 cases of drug induced liver disease were randomly divided into the study group and the control group,30 cases in each.The study group was intravenously injected with SNMC 60mL dissolved in 5% glucose 250mL,once per day.The control group was intravenously injected with reduced glutathione 1 200mg dissolved in 5% Glucose 250mL once per day.The treatment course for both groups was four weeks .RESULTS： The overall efficacy rates of the study group and the control group were 96.7% and 93.3% respectively（P〈0.05） .There were 2 cases of slight headache in the study group and 1 case of slight dizziness in the control group,which were all relieved after application of symptomatic treatment without reducing dosage or discontinuing administration.CONCLUSION： The therapeutic -ffect of SNMC on drug introduced liver disease is equivalent with that of reduced glutathione.SNMC can be used on drug - induced liver disease.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第2期130-131,共2页
China Pharmacy
关键词
复方甘草酸苷
药物性肝病
还原型谷胱甘肽
Stronger neo-minophagen C
Drug-induced liver disease
Reduced glutathione
