摘要
近年来研究证实CD40分子与其配体CD40L在动脉粥样硬化的各个阶段均起重要作用。动脉粥样硬化的关键细胞成分——内皮细胞、巨噬细胞和平滑肌细胞上均有CD40和CD40L表达,两者结合能诱导人血管内皮细胞表达多种活性介质,参与动脉粥样硬化斑块的形成,而阻断CD40- CD40L通路可防止动脉粥样硬化或阻止已形成的斑块进展。CD40L可能参与血栓形成和血小板活化,急性脑梗死和急性冠状动脉综合征患者血液中的可溶性CD40L持续性增高。一些药物能够下调CS40L水平,为预防血管事件的发生提供了一个新的途径。
Recent studies have confirmed that both CD40 molecule and its ligand CD40L played important roles in various stages of atherosclerosis, The critical cell component of atherosclerosisendothelial cells, macrophages, and smooth muscle cells on which there are expressions of CD40 and CD40L Toe combination of both induces human vascular endothelial cells expressing various active media, participating in the formation of atherosclerosis. However, blocking the CD40-CD40L pathway can wevent atherosclerosis or prevent the plaques from progressing. CD40L may participate in thrombosis and activation of platelet. The soluble CD40L levels increase persistently in patients with acnte cerebral infarction and acute coronary syndrome. Some drugs may down-regulate CD40L lexel. It has provided a new approach for prexenting the occurrence of vascular events.
出处
《国际脑血管病杂志》
2006年第11期862-864,共3页
International Journal of Cerebrovascular Diseases
