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多沙唑嗪有效改善BPH患者排尿症状 被引量:1

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摘要 为分析多沙唑嗪治疗BPH患者排尿期失调的临床和尿动力学疗效,Esteban Fuertes M等对65例BPH患者连续服用多沙唑嗪(4mg/d)6个月(年龄54岁-79岁,平均66.7岁)的临床和尿动力学状况进行前瞻性研究。临床评价包括患者病史、IPSS评分,尿动力学评价包括排尿后残余尿量和压力-尿流等尿流参数测试。并分析排尿时静尿道压力状况。治疗后(11.9/4.6)IPSS评分较治疗前(19.8/4.8)有显著改善(P〈0.001)。IPSS评分较低患者的排尿症状改善尤为明显(coeff.-0.45939),IPSS评分展示改善程度并不与DRE或前列腺体积(经腹B超)相关。平均最大屎流率由治疗前的9.13ml/s上升至术后的16.23ml/s(P〈0.01),残余尿量由治疗前的21.7%下降至治疗后的12.5%(P〈0.01)。压力尿流测试显示基点PURR从治疗前69cmsH20降到治疗后45.9cmsH2O,差异显著(P〈0.001)。反应下尿路梗阻的压缩性(P〈0.001)和收缩性(P〈0.05)参数均显著改善。功能性尿道长度由治疗前的5.56cms,下降至治疗后的4.31ClIIS(P〈0.05),治疗后尿道功能长度和基点PURR相关。由此表明,a1受体阻断剂多沙唑嗪对BPH患者的排尿期下尿路梗阻压缩性和收缩性参数均有显著的改善作用。
作者 周晓峰
出处 《中国男科学杂志》 CAS CSCD 2006年第12期2-2,共1页 Chinese Journal of Andrology
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