摘要
目的:利用α-磷酸三钙和羟基磷灰石复合,制备出具有一定强度的生物活性骨水泥。方法:实验于2003-09/2005-01在兰州交通大学材料系实验室完成。首先利用化学沉淀法合成羟基磷灰石粉末,然后利用固相反应制备α-磷酸三钙粉末,将其二者按一定比例混合均匀制得骨水泥粉料,最后用固化液(25%柠檬酸+70%去离子水+5%柠檬酸钾)调和制得骨水泥。结果:①沉淀法制备羟基磷灰石粉末中主要是羟基磷灰石相,含量高达99.5%,所有杂质相含量低于0.5%。②α-磷酸三钙粉末与羟基磷灰石粉末按不同配比混合后粉剂中仅存在两个晶相:羟基磷灰石/高温型磷酸三钙。③两相骨水泥的压缩强度已基本达到规定要求(≥30MPa),但弯曲强度仍较低。其中T50H50强度较高。④固化体在37℃生理盐水中浸渍2个月后,α-磷酸三钙含量明显减少,羟基磷灰石晶相大量增加,无新的结晶相生成。结论:制备的骨水泥克服了陶瓷型羟基磷灰石烧结形成、修整困难等缺点,具有制备容易、使用方便、固化时放热小等优点,可应用于体内骨修复材料。
AIM： Mixing alpha-tricalcium phosphate （ct-TCP） with hydroxyapatite ceramic （HAP） to produce biological active bone cement with certain strength. METHODS： The experiment was completed in the material department laboratory of Lanzhou Jiaotong University from September 2003 to January 2005. Firstly, chemical sediment method to synthesize HAP powder was used. Secondly, solid reaction was used to produceα-TCP powder, and then mixing them to produce bone cement power according to a certain proportion. Finally, with firming agent （citric acid 25%＋deionized water 70%＋potassium citrate 5%） to temper it and made into bone cement. RESULTS： ①The HAP powder which was made by chemical sediment method was mainly hydroxyapatite phase. The content was up to 99.5%, and all other impurity was low to 0.5%. ②The mixing powder which mixing α-TCP with HAP according to a certain proportion only had two crystalline phases： hydroxyapatite phase and high temperature tricalcium phosphate phase. ③The compression strength of the bone cement had already attained the prescript （≥30 MPa）, but the bending strength was still lower. Among them, the strength of T50H50 was higher. ④After two- month reaction hardened body was immersed in the normal saline at 37 ℃, the content of TCP reduced obviously and the content of HAP increased, having no new phase born. CONCLUSION： The made bone cement can be widely used as a new artificial bone substitute material. It is free from the drawback of ceramic HAP, including sintering and difficulties in shaping. It has the characteristics of simple-producing and easy application and lower heat energy, etc.
出处
《中国临床康复》
CSCD
北大核心
2006年第45期65-67,I0006,共4页
Chinese Journal of Clinical Rehabilitation
