摘要
目的检测与分析上皮细胞钙粘蛋白(上皮钙粘附素,E-cadherin),CD44变异体6(CD44varient6,CD44v6)在子宫腺肌病(adenomyosis,AM)在位内膜及异位内膜细胞中的表达情况及相关性,探讨其在AM发病中的作用。方法采用免疫组化Envision法检测正常子宫内膜,AM的在位内膜、异位内膜组织中E-cadherin,CD44v6的表达,采用SPSS13.0统计软件对实验数据进行统计学分析。结果E-cadherin在AM在位内膜和异位内膜的表达,较正常子宫内膜弱,差异有显著意义(P<0.05);CD44v6在AM在位内膜和异位内膜的表达,较正常子宫内膜强,差异有显著意义(P<0.05)。AM异位内膜和在位内膜中,E-cadherin和CD44v6的表达,呈负相关(P<0.05);正常内膜中,E-cadherin和CD44v6的表达无明显相关性(P>0.05)。结论E-cadherin,CD44v6在AM在位内膜及异位内膜细胞中表达异常,提示其可能在AM的发生发展中起重要作用;E-cadherin,CD44v6在AM在位内膜及异位内膜细胞中表达有相关性,提示二者在AM的发生发展中有协同作用。
Objective To observe the expression of E-cadherin and CD44v6 in human adenomyosis. To explore the correlation between the expression of E-cadherin and CD44 v6 in the pathogenesis of adenomyosis. Methods The expression of E-cadherin and CD44v6 in 50 ectopie and eutopic endometrium of adenomyosis was detected by immunohistoehemieal method in comparison with 30 normal endometrium. Results were analyzed by SPSS13.0 statistical software. Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium （P〈0. 05）. The expression of CD44v6 in ectopie and eutopic endometrium of adenomyosis is higher than that in normal endometrium（P〈0.05）. There was a negative correlation between the expression of E-cadherin and CD44 v6 in eutopic cndometrium of adenomyosis and eetopic endometrium of adenomyosis （P〈0. 05）. There was no correlation between the expression of E-cadherin and CD44v6 in normal endometrium （Pi〉0.05）. Conclusion The abnormal expression of E cadherin and CD44v6 in eutopie endometrium and ectopic endometrium has relationship with the etiology of adenomyosis.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2006年第6期315-317,共3页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
广东省科委基金资助项目(2006B35930003)
