1Tobe K, Ogura J, TsukamOto C, et al. Relationship between serum leptin and fatty liver in Japanese male adolescent university student. Am J gestroenterol, 1999,94(11):3328-3335.
2Ahima RS, Flier JS. leptin. Annu Rev Physiol. 2000,62:413-437.
3Kojima M, hosoda H, Date Y, et al. Ghrelin is a growth.honnone-releasing acylated peptide from stomach. Nature, 1999,402(6762):656-660.
4Kamegai J, Tamura H, Shimizu T, et al. Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic gene expression. Endocrinology, 2000,141 (12) :4797-4800.
6Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and metabolic syndrome. Hepatology, 2003,37 (4) : 917-923.
7Considine RV, Sinha MK, Heiman ML, et al. Srum immunoreactive leptin concentrations in normal weight and obese humans. N Engl J Med, 1996,334(5): 292-295.
8Banks WA, Coon AB, Robinson SM, et al. Triglycerides induce leptin resistance at the blooα-brain-barrier. Diabetes, 2003,53 (5) : 1253-1260.
9Huang W, Dedousis N, Bhatt BA, et al. Impaired Activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity[J]. Biol Chem,2004,279(21):21695-21700.
10Burguera B,Counce ME,Curran GL,et al. Obsity is associated with a decreased leptin transport across the bolld-brain-barrler in rat. Diabete,2000,49(7): 1219-1223.
4Akira K, Hideki U, Esteban C, et al. Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus [J]. J Eur Endocrinol, 2004, 151 (5): 573-577.
5Xu A, Wang Y, Hussila K, et al. The fat-derived hormone adiponectin alleviates al-coholic and nonalcoholic fatty liver diseases in mice [J]. Clin Invest, 2003, 112 (1): 91-100.
6Scheen AJ. Pathophysiology of type 2 diabetes [J]. Acta Clin Belg, 2003, 58 (6): 335-341.
7Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30 kDa adi-pocyte comp lement-related protein increases fatty acid oxidation in muscle and causes weight lose in mice [J]. Proe Natl Acad Sci USA, 2001, 98 (4) : 2005 2010.
8HottaK, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocytep rotein adiponectin are decreased in parallel with reduced insulin sensitivity during thep rogression to type 2 diabetes in rhesus monkeys [J].Diabetes, 2001, 50 ( 5 ): 1126-1133.
9Matsuda M, Shimomura I, Sata M, et al. Role of adiponeetin in preventing vascular stenosis. The missing link of adipo-vascular axis [J]. J Biol Chem, 2002, 277: 37487- 37491.
10Kojiraa M, Hosoda H, Date Y, et al. Ghrelin is a growth- hormone releasing aeylated peptide from stomach [J]. Nature, 1999, 402 (6762): 656.
